The RNA-binding protein human antigen R (HuR) is a well-established regulator of gene
expression at the posttranscriptional level. Its dysregulation has been implicated in various …

Introduction In fragment-based drug design, fragment linking is a popular strategy where two
fragments binding to different sub-pockets of a target are linked together. This attractive …

In recent years, RNA has gained traction both as a therapeutic molecule and as a
therapeutic target in several human pathologies. In this review, we consider the approach of …

In recent years, advances in biomedicine have revealed an important role for post-
transcriptional mechanisms of gene expression regulation in pathologic conditions. In …

The RNA-binding protein human antigen R (HuR) regulates stability, translation, and
nucleus-to-cytoplasm shuttling of its target mRNAs. This protein has been progressively …

Cardiac fibrosis can be mitigated by limiting fibroblast-to-myofibroblast differentiation and
proliferation. Human antigen R (HuR) modulates messenger RNA stability and expression of …

Cancer is a disease that poses a serious threat to human health, the occurrence and
development of which involves complex molecular mechanisms. Long non-coding RNAs …

RNA-binding proteins (RBPs) refer to a class of proteins that participate in alternative
splicing, RNA stability, polyadenylation, localization and translation of RNAs, thus regulating …

RNA‐binding proteins (RBPs) play vital roles in organisms through binding with RNAs to
regulate their functions. Small molecules affecting the function of RBPs have been …

In dieser Arbeit wird die Funktion des RNA-bindenden humanen Antigen R Proteins (HuR)
und seine Arzneitauglichkeit mithilfe computergestützter Methoden untersucht. HuR reguliert …