Pericytes in Alzheimer's disease: Key players and therapeutic targets

Y Zhang, BR Mu, Z Ran, T Zhu, X Huang, X Yang… - Experimental …, 2024 - Elsevier
Alzheimer's disease (AD) is a devastating neurodegenerative disorder that leads to
progressive cognitive decline and neuropathological changes. Pericytes, which are vessel …

Understanding current experimental models of glioblastoma-brain microenvironment interactions

N Yadav, BW Purow - Journal of Neuro-oncology, 2024 - Springer
Glioblastoma (GBM) is a common and devastating primary brain tumor, with median survival
of 16–18 months after diagnosis in the setting of substantial resistance to standard-of-care …

Activated STING-containing R-EVs from iPSC-derived MSCs promote antitumor immunity

L Qian, Z Zhang, R Zhang, X Zheng, B Xiao, X Zhang… - Cancer Letters, 2024 - Elsevier
We recently revealed that activated STING is secreted into RAB22A-induced extracellular
vesicles (R-EVs) and promotes antitumor immunity in cancer cells. Whether mesenchymal …

Unravelling role of crocin for the treatment of Alzheimer's and Parkinson's disease: sojourn from food to nanomedicine

H Kaur, B Bashir, A Kaur, N Singh, S Vishwas… - Phytochemistry …, 2024 - Springer
Flavonoids have a longstanding tradition of being employed in traditional medicine to
improve human health. Crocin has been suggested as a potential candidate for addressing …

Exosomes in Vascular/Neurological Disorders and the Road Ahead

FA Alzahrani, YM Riza, TM Eid, R Almotairi… - Cells, 2024 - mdpi.com
Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD),
amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), stroke, and aneurysms, are …

MSC-derived exosomal miR-140-3p improves cognitive dysfunction in sepsis-associated encephalopathy by HMGB1 and S-lactoylglutathione metabolism

Y Ma, X She, Y Liu, X Qin - Communications Biology, 2024 - nature.com
MiRNAs in mesenchymal stem cells (MSCs)-derived exosome (MSCs-exo) play an
important role in the treatment of sepsis. We explored the mechanism through which MSCs …

Mesenchymal stem cell‐derived exosomes improve neurogenesis and cognitive function of mice with methamphetamine addiction: A novel treatment approach

S Fallahi, HS Zangbar, F Farajdokht… - CNS Neuroscience …, 2024 - Wiley Online Library
Background Methamphetamine (METH) is a psychostimulant substance with highly
addictive and neurotoxic effects, but no ideal treatment option exists to improve METH …

Extracellular Vesicles Loaded with Long Antisense RNAs Repress Severe Acute Respiratory Syndrome Coronavirus 2 Infection

A Idris, S Shrivastava, A Supramaniam… - nucleic acid …, 2024 - liebertpub.com
Long antisense RNAs (asRNAs) have been observed to repress HIV and other virus
expression in a manner that is refractory to viral evolution. Severe acute respiratory …

A homotopy-based computational scheme for two-dimensional fractional cable equation

CVD Kumar, DG Prakasha, P Veeresha… - … Physics Letters B, 2024 - World Scientific
In this paper, we examine the time-dependent two-dimensional cable equation of fractional
order in terms of the Caputo fractional derivative. This cable equation plays a vital role in …

[HTML][HTML] Application of Multiomics Approach to Investigate the Therapeutic Potentials of Stem Cell-derived Extracellular Vesicle Subpopulations for Alzheimer's …

M Abyadeh, A Kaya - bioRxiv, 2024 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) presents a complex interplay of molecular alterations, yet
understanding its pathogenesis remains a challenge. In this study, we delved into the …