Diabetic nephropathy: significance of determining oxidative stress and opportunities for antioxidant therapies
M Darenskaya, S Kolesnikov, N Semenova… - International Journal of …, 2023 - mdpi.com
Diabetes mellitus (DM) belongs to the category of socially significant diseases with epidemic
rates of increases in prevalence. Diabetic nephropathy (DN) is a specific kind of kidney …
rates of increases in prevalence. Diabetic nephropathy (DN) is a specific kind of kidney …
The nicotinamide/streptozotocin rodent model of type 2 diabetes: Renal pathophysiology and redox imbalance features
LJ Yan - Biomolecules, 2022 - mdpi.com
Diabetic nephropathy (DN) is a common complication of diabetes mellitus. While there has
been a great advance in our understanding of the pathogenesis of DN, no effective …
been a great advance in our understanding of the pathogenesis of DN, no effective …
[HTML][HTML] Alpha-lipoic acid treatment improves adverse cardiac remodelling in the diabetic heart–The role of cardiac hydrogen sulfide-synthesizing enzymes
Introduction Alpha-lipoic acid (ALA) is a licensed drug for the treatment of diabetic
neuropathy. We recently reported that it also improves diabetic cardiomyopathy (DCM) in …
neuropathy. We recently reported that it also improves diabetic cardiomyopathy (DCM) in …
[HTML][HTML] Activation of renal CSE/H2S pathway by alpha-lipoic acid protects against histological and functional changes in the diabetic kidney
GJ Dugbartey, KK Alornyo, DE Diaba… - Biomedicine & …, 2022 - Elsevier
Introduction We previously reported that alpha-lipoic acid (ALA) supplementation protects
against progression of diabetic kidney disease (DKD). In this study, we aim to investigate …
against progression of diabetic kidney disease (DKD). In this study, we aim to investigate …
Targeting hepatic sulfane sulfur/hydrogen sulfide signaling pathway with α-lipoic acid to prevent diabetes-induced liver injury via upregulating hepatic CSE/3-MST …
Background Diabetes-induced liver injury is a complication of diabetes mellitus of which
there are no approved drugs for effective treatment or prevention. This study investigates …
there are no approved drugs for effective treatment or prevention. This study investigates …
CircUBXN7 promotes macrophage infiltration and renal fibrosis associated with the IGF2BP2-dependent SP1 mRNA stability in diabetic kidney disease
Z Lin, D Lv, X Liao, R Peng, H Liu, T Wu, K Wu… - Frontiers in …, 2023 - frontiersin.org
Introduction Inflammatory cell infiltration is a novel hallmark of diabetic kidney disease
(DKD), in part, by activated macrophages. Macrophage-to-tubular epithelial cell …
(DKD), in part, by activated macrophages. Macrophage-to-tubular epithelial cell …
Hepatoprotective potential of alpha-lipoic acid against gliclazide-induced liver injury in high-glucose-exposed human liver cells and experimental type 2 diabetic rats
Growing clinical evidence shows that sulfonylurea therapy for patients with type 2 diabetic
mellitus (T2DM) contributes to progressive worsening of their liver. The present study …
mellitus (T2DM) contributes to progressive worsening of their liver. The present study …
Ameliorative effect of Metformin/alpha-lipoic acid combination on diabetic nephropathy via modulation of YAP/miR-29a/PTEN/p-AKT axis
SA Helmy, OA Nour, G Al Shaima - International Immunopharmacology, 2024 - Elsevier
Diabetic nephropathy (DN) is the most frequent and serious complication of type 2 diabetes
(T2DM). Lack of a precise remedy and socio-economic burden of DN patients implements …
(T2DM). Lack of a precise remedy and socio-economic burden of DN patients implements …
Expert opinion on screening, diagnosis and management of diabetic peripheral neuropathy: a multidisciplinary approach
A Atmaca, A Ketenci, I Sahin, IS Sengun… - Frontiers in …, 2024 - frontiersin.org
The proposed expert opinion aimed to address the current knowledge on conceptual,
clinical, and therapeutic aspects of diabetic peripheral neuropathy (DPN) and to provide a …
clinical, and therapeutic aspects of diabetic peripheral neuropathy (DPN) and to provide a …
Approach to correction of apoptotic disorders in children with early diabetic nephropathy
I Burlaka - Journal of Advanced Pharmacy Education and …, 2022 - japer.in
Abstract hypertension, and a decline in renal function. Prominent changes detected in
apoptosis controlling factors, ie BcL-xL and caspase-3 and require a search for additional …
apoptosis controlling factors, ie BcL-xL and caspase-3 and require a search for additional …