Diabetic nephropathy: significance of determining oxidative stress and opportunities for antioxidant therapies

M Darenskaya, S Kolesnikov, N Semenova… - International Journal of …, 2023 - mdpi.com
Diabetes mellitus (DM) belongs to the category of socially significant diseases with epidemic
rates of increases in prevalence. Diabetic nephropathy (DN) is a specific kind of kidney …

The nicotinamide/streptozotocin rodent model of type 2 diabetes: Renal pathophysiology and redox imbalance features

LJ Yan - Biomolecules, 2022 - mdpi.com
Diabetic nephropathy (DN) is a common complication of diabetes mellitus. While there has
been a great advance in our understanding of the pathogenesis of DN, no effective …

[HTML][HTML] Alpha-lipoic acid treatment improves adverse cardiac remodelling in the diabetic heart–The role of cardiac hydrogen sulfide-synthesizing enzymes

GJ Dugbartey, QL Wonje, KK Alornyo, I Adams… - Biochemical …, 2022 - Elsevier
Introduction Alpha-lipoic acid (ALA) is a licensed drug for the treatment of diabetic
neuropathy. We recently reported that it also improves diabetic cardiomyopathy (DCM) in …

[HTML][HTML] Activation of renal CSE/H2S pathway by alpha-lipoic acid protects against histological and functional changes in the diabetic kidney

GJ Dugbartey, KK Alornyo, DE Diaba… - Biomedicine & …, 2022 - Elsevier
Introduction We previously reported that alpha-lipoic acid (ALA) supplementation protects
against progression of diabetic kidney disease (DKD). In this study, we aim to investigate …

Targeting hepatic sulfane sulfur/hydrogen sulfide signaling pathway with α-lipoic acid to prevent diabetes-induced liver injury via upregulating hepatic CSE/3-MST …

GJ Dugbartey, KK Alornyo, I Adams, S Atule… - Diabetology & metabolic …, 2022 - Springer
Background Diabetes-induced liver injury is a complication of diabetes mellitus of which
there are no approved drugs for effective treatment or prevention. This study investigates …

CircUBXN7 promotes macrophage infiltration and renal fibrosis associated with the IGF2BP2-dependent SP1 mRNA stability in diabetic kidney disease

Z Lin, D Lv, X Liao, R Peng, H Liu, T Wu, K Wu… - Frontiers in …, 2023 - frontiersin.org
Introduction Inflammatory cell infiltration is a novel hallmark of diabetic kidney disease
(DKD), in part, by activated macrophages. Macrophage-to-tubular epithelial cell …

Hepatoprotective potential of alpha-lipoic acid against gliclazide-induced liver injury in high-glucose-exposed human liver cells and experimental type 2 diabetic rats

GJ Dugbartey, S Atule, KK Alornyo, I Adams - Biochemical Pharmacology, 2024 - Elsevier
Growing clinical evidence shows that sulfonylurea therapy for patients with type 2 diabetic
mellitus (T2DM) contributes to progressive worsening of their liver. The present study …

Ameliorative effect of Metformin/alpha-lipoic acid combination on diabetic nephropathy via modulation of YAP/miR-29a/PTEN/p-AKT axis

SA Helmy, OA Nour, G Al Shaima - International Immunopharmacology, 2024 - Elsevier
Diabetic nephropathy (DN) is the most frequent and serious complication of type 2 diabetes
(T2DM). Lack of a precise remedy and socio-economic burden of DN patients implements …

Expert opinion on screening, diagnosis and management of diabetic peripheral neuropathy: a multidisciplinary approach

A Atmaca, A Ketenci, I Sahin, IS Sengun… - Frontiers in …, 2024 - frontiersin.org
The proposed expert opinion aimed to address the current knowledge on conceptual,
clinical, and therapeutic aspects of diabetic peripheral neuropathy (DPN) and to provide a …

Approach to correction of apoptotic disorders in children with early diabetic nephropathy

I Burlaka - Journal of Advanced Pharmacy Education and …, 2022 - japer.in
Abstract hypertension, and a decline in renal function. Prominent changes detected in
apoptosis controlling factors, ie BcL-xL and caspase-3 and require a search for additional …