Natural killer (NK) cells belong to the innate immune system and contribute to protecting the
host through killing of infected, foreign, stressed or transformed cells. Additionally, via …

The modern biopharmaceutical industry traces its roots to the dawn of the twentieth century,
coincident with marketing of aspirin—a signature event in the history of modern drug …

Objective Natural killer (NK) cells play a critical role in the innate antitumor immune
response. Recently, NK cell dysfunction has been verified in various malignant tumors …

Natural Killer (NK) cells are characterized by their potential to kill tumor cells by different
means without previous sensitization and have, therefore, become a valuable tool in cancer …

Natural killer (NK) cells are a critical component of the innate immune system. Chimeric
antigen receptors (CARs) re-direct NK cells toward tumor cells carrying corresponding …

Oncolytic viruses (OVs) are powerful new therapeutic agents in cancer therapy. With the first
OV (talimogene laherparepvec [T-vec]) obtaining US Food and Drug Administration …

Chimeric antigen receptors (CARs) are fusion proteins with an extracellular antigen
recognition domain and numerous intracellular signaling domains that have been …

Natural killer (NK) cells are lymphocytes of the innate immune response characterized by
their role in the destruction of tumor cells. Activation of NK cells depend on a fine balance …

Natural killer (NK) cells are attractive within adoptive transfer settings in cancer
immunotherapy due to their potential for allogeneic use; their alloreactivity is enhanced …

Abstract Immune-checkpoint inhibitors (ICI), although revolutionary in improving long-term
survival outcomes, are mostly effective in patients with immune-responsive tumors. Most …