To date, more than 30 genes have been linked to monogenic diabetes. Candidate gene and
genome-wide association studies have identified> 50 susceptibility loci for common type 1 …

At least 20 different chromosomal regions have been linked to type 1 diabetes (T1D)
susceptibility in humans, using genome screening, candidate gene testing, and studies of …

MafA is a transcription factor that binds to the promoter in the insulin gene and has been
postulated to regulate insulin transcription in response to serum glucose levels, but there is …

Aims/hypothesis: Five different types of maturity-onset diabetes of the young (MODY) have
been identified until now but mutation screening suggests that more MODY genes exist …

NeuroD (otherwise known as BETA2) is a basic helixloop-helix (bHLH) transcription factor
that is capable of converting embryonic epidermal cells into fully differentiated neurons in …

Mutations in the genes encoding hepatocyte nuclear factor 4α (HNF-4α) and HNF-1α impair
insulin secretion and cause maturity onset diabetes of the young (MODY). HNF-4α is known …

Lack of insulin production or abnormalities affecting insulin secretion are key to the
development of almost all forms of diabetes, including the common type 1 (insulin …

BETA2/NeuroD, a basic helix-loop-helix transcription factor, is a key regulator of pancreatic
islet morphogenesis and insulin gene transcription. Here we report for the first time that the …

Autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy (APECED) is a rare
autosomal recessive disorder characterized by an immune-mediated destruction of …

Throughout the last decade, molecular genetic studies of non‐autoimmune diabetes mellitus
have contributed significantly to our present understanding of this disease's complex …