Heat shock proteins: Biological functions, pathological roles, and therapeutic opportunities
The heat shock proteins (HSPs) are ubiquitous and conserved protein families in both
prokaryotic and eukaryotic organisms, and they maintain cellular proteostasis and protect …
prokaryotic and eukaryotic organisms, and they maintain cellular proteostasis and protect …
HSP70 and primary arterial hypertension
Heat shock protein 70 (HSP70) production is a stress-generated cellular response with high
interspecies homology. HSP70 has both chaperone and cytokine functions and may induce …
interspecies homology. HSP70 has both chaperone and cytokine functions and may induce …
[HTML][HTML] Current biomarkers and treatment strategies in Alzheimer disease: An overview and future perspectives
Abstract Alzheimer's disease (AD), a progressive degenerative disorder first identified by
Alois Alzheimer in 1907, poses a significant public health challenge. Despite its prevalence …
Alois Alzheimer in 1907, poses a significant public health challenge. Despite its prevalence …
Exploring the immunomodulatory effects and mechanisms of Xinjiang fermented camel milk-derived bioactive peptides based on network pharmacology and …
Y Wang, Z Liang, F Shen, W Zhou, T Manaer… - Frontiers in …, 2023 - frontiersin.org
Purpose: Fermented camel milk from Xinjiang is rich in probiotics and has
immunomodulatory effects as an important source of bioactive peptides. However, it is not …
immunomodulatory effects as an important source of bioactive peptides. However, it is not …
Incorporating the molecular mimicry of environmental antigens into the causality of autoimmune hepatitis
AJ Czaja - Digestive Diseases and Sciences, 2023 - Springer
Molecular mimicry between foreign and self-antigens has been implicated as a cause of
autoimmune hepatitis in experimental models and cross-reacting antibodies in patients. This …
autoimmune hepatitis in experimental models and cross-reacting antibodies in patients. This …
The complement system as a key modulator of the oral microbiome in health and disease
RO Mattos-Graner, MI Klein… - Critical Reviews in …, 2024 - Taylor & Francis
In this review, we address the interplay between the complement system and host
microbiomes in health and disease, focussing on oral bacteria known to contribute to …
microbiomes in health and disease, focussing on oral bacteria known to contribute to …
Complexity of the Immune Response Elicited by Different COVID-19 Vaccines, in the Light of Natural Autoantibodies and Immunomodulatory Therapies
K Böröcz, Á Kinyó, D Simon, S Erdő-Bonyár… - International Journal of …, 2023 - mdpi.com
Despite the abundance of data on the COVID-19 vaccine-induced immune activation, the
impact of natural autoantibodies (nAAbs) on these processes is less well defined. Therefore …
impact of natural autoantibodies (nAAbs) on these processes is less well defined. Therefore …
Proteome analysis, bioinformatic prediction and experimental evidence revealed immune response down-regulation function for serum-starved human fibroblasts
N Jafari, R Gheitasi, HR Khorasani, M Golpour… - Heliyon, 2023 - cell.com
Emerging evidence indicates that fibroblasts play pivotal roles in immunoregulation by
producing various proteins under health and disease states. In the present study, for the first …
producing various proteins under health and disease states. In the present study, for the first …
Emerging roles of tyrosine kinases in hepatic inflammatory diseases and therapeutic opportunities
Inflammation has been convicted of causing and worsening many liver diseases like acute
liver failure, fibrosis, cirrhosis, fatty liver and liver cancer. Pattern recognition receptors …
liver failure, fibrosis, cirrhosis, fatty liver and liver cancer. Pattern recognition receptors …
A “defend–attack and capture flag” strategy for cascade management of hepatic ischemia reperfusion injury
W Zhang, Z Shen, C Li, Y Yang, T Zhang, BY Yu… - Chemical Engineering …, 2024 - Elsevier
Hepatic ischemia reperfusion injury (HIRI) following transplantation or resection can lead to
irreversible liver dysfunction and even failure, yet current therapeutic interventions are …
irreversible liver dysfunction and even failure, yet current therapeutic interventions are …