Heat shock proteins: Biological functions, pathological roles, and therapeutic opportunities

C Hu, J Yang, Z Qi, H Wu, B Wang, F Zou, H Mei… - MedComm, 2022 - Wiley Online Library
The heat shock proteins (HSPs) are ubiquitous and conserved protein families in both
prokaryotic and eukaryotic organisms, and they maintain cellular proteostasis and protect …

HSP70 and primary arterial hypertension

B Rodriguez-Iturbe, RJ Johnson, LG Sanchez-Lozada… - Biomolecules, 2023 - mdpi.com
Heat shock protein 70 (HSP70) production is a stress-generated cellular response with high
interspecies homology. HSP70 has both chaperone and cytokine functions and may induce …

[HTML][HTML] Current biomarkers and treatment strategies in Alzheimer disease: An overview and future perspectives

RP Bhole, RV Chikhale, KM Rathi - IBRO neuroscience reports, 2023 - Elsevier
Abstract Alzheimer's disease (AD), a progressive degenerative disorder first identified by
Alois Alzheimer in 1907, poses a significant public health challenge. Despite its prevalence …

Exploring the immunomodulatory effects and mechanisms of Xinjiang fermented camel milk-derived bioactive peptides based on network pharmacology and …

Y Wang, Z Liang, F Shen, W Zhou, T Manaer… - Frontiers in …, 2023 - frontiersin.org
Purpose: Fermented camel milk from Xinjiang is rich in probiotics and has
immunomodulatory effects as an important source of bioactive peptides. However, it is not …

Incorporating the molecular mimicry of environmental antigens into the causality of autoimmune hepatitis

AJ Czaja - Digestive Diseases and Sciences, 2023 - Springer
Molecular mimicry between foreign and self-antigens has been implicated as a cause of
autoimmune hepatitis in experimental models and cross-reacting antibodies in patients. This …

The complement system as a key modulator of the oral microbiome in health and disease

RO Mattos-Graner, MI Klein… - Critical Reviews in …, 2024 - Taylor & Francis
In this review, we address the interplay between the complement system and host
microbiomes in health and disease, focussing on oral bacteria known to contribute to …

Complexity of the Immune Response Elicited by Different COVID-19 Vaccines, in the Light of Natural Autoantibodies and Immunomodulatory Therapies

K Böröcz, Á Kinyó, D Simon, S Erdő-Bonyár… - International Journal of …, 2023 - mdpi.com
Despite the abundance of data on the COVID-19 vaccine-induced immune activation, the
impact of natural autoantibodies (nAAbs) on these processes is less well defined. Therefore …

Proteome analysis, bioinformatic prediction and experimental evidence revealed immune response down-regulation function for serum-starved human fibroblasts

N Jafari, R Gheitasi, HR Khorasani, M Golpour… - Heliyon, 2023 - cell.com
Emerging evidence indicates that fibroblasts play pivotal roles in immunoregulation by
producing various proteins under health and disease states. In the present study, for the first …

Emerging roles of tyrosine kinases in hepatic inflammatory diseases and therapeutic opportunities

ME Shaker, HAM Gomaa, MA Abdelgawad… - International …, 2023 - Elsevier
Inflammation has been convicted of causing and worsening many liver diseases like acute
liver failure, fibrosis, cirrhosis, fatty liver and liver cancer. Pattern recognition receptors …

A “defend–attack and capture flag” strategy for cascade management of hepatic ischemia reperfusion injury

W Zhang, Z Shen, C Li, Y Yang, T Zhang, BY Yu… - Chemical Engineering …, 2024 - Elsevier
Hepatic ischemia reperfusion injury (HIRI) following transplantation or resection can lead to
irreversible liver dysfunction and even failure, yet current therapeutic interventions are …