Immortalized cell lines are widely used in vitro tools in oncology and hematology research.
While these cell lines represent artificial systems and may accumulate genetic aberrations …

PLAY an integral role in maintaining adequate hemostasis. However, the process by which
platelets are produced is not well understood. Rodent and human models have been used …

Abstract CD40 ligand (CD40L, CD154), a transmembrane protein structurally related to the
cytokine TNF-α, was originally identified on stimulated CD4+ T cells,,, and later on …

Lysophosphatidic acid (LPA) is a bioactive lipid mediator with diverse physiological and
pathological actions on many types of cells. LPA has been widely considered to elicit its …

THROMBOXANE A2 is a very unstable arachidonate metabolite, yet a potent stimulator of
platelet aggregation and a constrictor of vascular and respiratory smooth muscles1. It has …

To clone the CD63 antigen, originally described as a blood platelet activation marker, we
adapted the expression cloning procedure of Seed and Aruffo (Seed, B., and Aruffo …

Antibody-targeted chemotherapy is a promising therapy in patients with acute myeloid
leukemia (AML). In a phase II study of Mylotarg (CMA-676, gemtuzumab ozogamicin), which …

Signal-regulatory proteins (SIRPs) comprise a novel transmembrane glycoprotein family
involved in the negative regulation of receptor tyrosine kinase-coupled signaling pathways …

The role of platelets in hemostasis and thrombosis is clearly established; however, the
mechanisms by which platelets mediate inflammatory and immune pathways are less well …

Injuries to the vessel wall and subsequent exposure of collagen from the subendothelial
matrix result in thrombus formation. In physiological conditions, the platelet plug limits blood …