Using a confocal microscope with a single-photon avalanche photodiode as detector, we
studied photon bursts of single Rhodamine 6G (R6G) and Rhodamin B-zwitterion (RB) …

It has long been the dream of chemists to examine a single molecule and monitor its
structural changes. The observation of a single molecule and its individual properties and …

Laser-induced fluorescence (LIF) detection of single fluorescent molecules represents the
ultimate level of sensitivity for fluorescence-based chemical assays. This has been …

The increased sensitivity together with the advent of low-cost optical sources and detectors
in the visible-near IR region has led us to current efforts to develop new efficient fluorescent …

(57) ABSTRACT A method for determining the length and velocity of single elongated
macromolecules is disclosed. In particular, the present invention relates to methods and …

We report a multiplex technique for identification of single fluorescent molecules in a flowing
sample stream by correlated measurement of single-molecule fluorescence burst size and …

Detection channels with submicrometer dimensions (500− 600 nm id) have been produced
directly on electrophoresis capillaries for confinement and detection of single molecules at …

We report the pulsed delivery of single-stranded DNA molecules through a nanopipet. The
conical geometry of the pipet leads to a localized electric field, since all of the potential drop …

To find feasibility of identifying nucleotides at the single-molecule level, we implemented
Raman imaging and spectroscopy of adenine molecules adsorbed on Ag colloidal …

A method has been developed for detecting DNA sepa-rated by capillary gel electrophoresis
(CGE) using single molecule photon burst counting. A confocal fluorescence microscope …