Protein aggregation has been recognized as one of the major challenges in the
development and commercialization of successful protein-based drug products because of …

Self-assembly of misfolded proteins into ordered fibrillar aggregates known as amyloid
results in various human diseases. However, more and more proteins, whether in human …

The recently emerged COVID-19 has been declared a pandemic by the World Health
Organization as to date; no therapeutic drug/vaccine is available for the treatment. Due to …

Accumulating research has linked Mediterranean diet (MeDi) adherence with slower
cognitive decline and reduced Alzheimer's disease (AD) risk. However, no study to-date has …

In the current study, ANS fluorescence was established as a powerful tool to study proteins
in solid-state. Silk fibroin from Bombyx mori cocoons was used as a paradigm protein. ANS …

Chitosan ascorbates with different substitution degrees were synthesized on the basis of
salification of chitosan and ascorbic acid at various molar ratios in water and were …

Misfolding proteins could form oligomers or amyloid fibers, which can cause a variety of
amyloid-associated diseases. Thus, the inhibition of protein misfolding and fibrillation is a …

Amyloid proteins were recognized as the crucial cause of many senile diseases. In this
study, the inhibitory effects of Sennoside A (SA) and Sennoside C (SC) on amyloid …

It has become increasingly apparent that defective insulin signaling may increase the risk for
developing Alzheimer's disease (AD), influence neurodegeneration through promotion of …

Novel coronavirus SARS-CoV-2 has infected millions of people with thousands of mortalities
globally. The main protease (Mpro) is vital in processing replicase polyproteins. Both the …