Objective Neutrophils are an important component of the inflammatory response that
characterizes acute lung injury (ALI). This discussion aims to review the contribution of …

The p38 kinase plays a central role in inflammation, and it has been the subject of extensive
efforts in both basic research and drug discovery. This review summarizes the biology of the …

Alveolar epithelial regeneration is essential for recovery from devastating lung diseases.
This process occurs when type II alveolar pneumocytes (AT2 cells) proliferate and …

Background: Hepatic ischemia reperfusion (IR) is an important issue in complex liver
resection and liver transplantation. The aim of the present study was to determine the …

The word “sepsis” comes from the Greek word sepo meaning decay or putrefaction, and its
original usage described the decomposition of organic matter in a manner that resulted in …

Foci of chondrocyte hypertrophy that commonly develop in osteoarthritic (OA) cartilage can
promote dysregulated matrix repair and pathologic calcification in OA. The closely related …

Recombinant human activated protein C (rhAPC) is a natural anticoagulant with potentially
important anti-inflammatory properties. In humans with severe sepsis, rhAPC treatment …

Mortality associated with acute lung injury (ALI) induced by lipopolysaccharide (LPS)
remains high in humans, warranting improved treatment and prevention strategies. ALI is …

The p38 subgroup of the mitogen-activated protein kinase superfamily has four isoforms:
p38α, p38β, p38δ and p38γ. Whereas p38α is involved in inflammation, proliferation …

The lung is continuously exposed to bacteria and their products, and has developed a
complex defense mechanism, including neutrophil recruitment. In mice, keratinocyte cell …