Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease–novel insights into cellular communication circuits
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease and is
emerging as the leading cause of cirrhosis, liver transplantation and hepatocellular …
emerging as the leading cause of cirrhosis, liver transplantation and hepatocellular …
[HTML][HTML] A review of neutrophil extracellular traps (NETs) in disease: potential anti-NETs therapeutics
V Mutua, LJ Gershwin - Clinical reviews in allergy & immunology, 2021 - Springer
Activated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of
stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of …
stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of …
Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome
COVID-19 affects millions of patients worldwide, with clinical presentation ranging from
isolated thrombosis to acute respiratory distress syndrome (ARDS) requiring ventilator …
isolated thrombosis to acute respiratory distress syndrome (ARDS) requiring ventilator …
[HTML][HTML] Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation
Lung metastasis is the major cause of breast cancer-related mortality. The neutrophil-
associated inflammatory microenvironment aids tumor cells in metastatic colonization in …
associated inflammatory microenvironment aids tumor cells in metastatic colonization in …
[HTML][HTML] The biology of lactoferrin, an iron-binding protein that can help defend against viruses and bacteria
DB Kell, EL Heyden, E Pretorius - Frontiers in immunology, 2020 - frontiersin.org
Lactoferrin is a nutrient classically found in mammalian milk. It binds iron and is transferred
via a variety of receptors into and between cells, serum, bile, and cerebrospinal fluid. It has …
via a variety of receptors into and between cells, serum, bile, and cerebrospinal fluid. It has …
Cellular mechanisms of NETosis
Neutrophils are critical to innate immunity, including host defense against bacterial and
fungal infections. They achieve their host defense role by phagocytosing pathogens …
fungal infections. They achieve their host defense role by phagocytosing pathogens …
Autoinflammation and autoimmunity across rheumatic and musculoskeletal diseases
Z Szekanecz, IB McInnes, G Schett… - Nature Reviews …, 2021 - nature.com
Most rheumatic and musculoskeletal diseases (RMDs) can be placed along a spectrum of
disorders, with autoinflammatory diseases (including monogenic systemic autoinflammatory …
disorders, with autoinflammatory diseases (including monogenic systemic autoinflammatory …
COVID‐19 and neutrophils: the relationship between hyperinflammation and neutrophil extracellular traps
Coronavirus disease 2019 (COVID‐19) is a virus‐induced respiratory disease that may
progress to acute respiratory distress syndrome (ARDS) and is triggered by …
progress to acute respiratory distress syndrome (ARDS) and is triggered by …
[HTML][HTML] DAMPs and NETs in sepsis
Sepsis is a deadly inflammatory syndrome caused by an exaggerated immune response to
infection. Much has been focused on host response to pathogens mediated through the …
infection. Much has been focused on host response to pathogens mediated through the …
Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice
INTRODUCTION Most cancer patients die from cancer that recurs after spreading to a
different tissue, rather than from their original tumor. After successful treatment of the original …
different tissue, rather than from their original tumor. After successful treatment of the original …