Purpose: Comprehensive genomic profiling (CGP) is of increasing value for patients with
metastatic castration-resistant prostate cancer (mCRPC). mCRPC tends to metastasize to …

Prostate cancer (PCa), known as a heterogenous disease, has a high incidence and
mortality rate around the world and seriously threatens public health. As an inevitable by …

Second-generation androgen receptor axis-targeted (ARAT) agents, namely abiraterone
and enzalutamide, enable stronger blockade of the androgen receptor (AR) axis and longer …

Androgen deprivation therapy is an important therapy for prostate cancer (PCa) in aging
men. Under the background of castration, it is inevitable that prostate cancer will develop …

Organisms have evolved to generate biological complexity in their proteome and
transcriptome from a limited number of genes. This concept holds true for the androgen …

Objective The bromodomain and extra-terminal (BET) family of proteins provides a
scaffolding platform for the recruitment and tethering of transcription factors to acetylated …

Introduction Metastatic prostate cancer is a life-threatening disease and an important public
health concern with prevalence rates varying drastically between high-and low-income …

Targeted therapies for cancer treatment utilize a range of small-molecule drugs or
monoclonal antibodies to influence cancer cell growth, survival, and spread. For prostate …

2018 has been another banner year in the progression of Precision Medicine! Year over
year, there has been a dramatic rise in the number of scientific studies and initiatives that …

As doenças da próstata atingem cerca de 80% dos homens com idade superior a 50 anos,
sendo que as duas formas mais comuns são a hiperplasia prostática benigna (HPB) e o …