Abstract The B Lymphocyte Stimulator (BLyS) family of ligands and receptors regulates
humoral immunity by controlling B lymphocyte survival and differentiation. Herein, we review …

Multiple myeloma (MM) remains an incurable disease, at least for the big majority of
patients, in spite of the great progress with new drugs in the last years. New treatment …

Objective: B lymphocytes have been implicated in the pathogenesis of lupus and other
autoimmune diseases, resulting in the introduction of B cell-directed therapies …

Many a disease associates with inflammation. Upon binding of antigen-antibody complexes
to immunoglobulin-like receptors, mast cells release tumor necrosis factor-α and proteases …

Naïve peripheral B cells survive in vivo because of active stimulation by the TNF superfamily
ligand B lymphocyte stimulator (BLyS/BAFF). Although the survival promoting properties of …

Vitiligo is the most frequent cause of depigmentation worldwide. Genetic association studies
have discovered about 50 loci associated with disease, many with immunological functions …

With an abundance of illustrations, diagrams, and algorithms, this sixth edition of Medical
Immunology provides a reader-friendly review of critical material on the current diagnostic …

B-cell receptor (BCR) signals are essential for B-cell differentiation, homeostasis and
negative selection, which are regulated by the strength and quality of BCR signals. Recently …

Systemic lupus erythematosus (SLE) is a complex immune disorder in which loss of
tolerance to nucleic acid antigens and other cross‐reactive antigens is associated with the …

Nuclear factor-kappaB (NF-κB) upregulates the transcription of proteins that promote cell
survival, stimulate growth, induce angiogenesis and reduce susceptibility to apoptosis. NF …