Low back pain stands as a pervasive global health concern, afflicting almost 80% of adults
at some point in their lives with nearly 40% attributable to intervertebral disc degeneration …

The messenger RNA (mRNA) vaccines hold great significance in contagion prevention and
cancer immunotherapy. However, safely and effectively harnessing innate immunity to …

Current mRNA vaccines are mainly administered via intramuscular injection, which induces
good systemic immunity but limited mucosal immunity. Achieving mucosal immunity through …

Among various mRNA carrier systems, lipid nanoparticles (LNPs) stand out as the most
clinically advanced. While current clinical trials of mRNA/LNP therapeutics mainly address …

T cell exhaustion has emerged as a major hurdle that impedes the clinical translation of
stimulator of interferon genes (STING) agonists. It is crucial to explore innovative strategies …

In the progression of X‐ray‐based radiotherapy for the treatment of cancer, the incorporation
of nanoparticles (NPs) has a transformative impact. This study investigates the potential of …

Colorectal cancer (CRC) is a common type of gastrointestinal tract (GIT) cancer and poses
an enormous threat to human health. Current strategies for metastatic colorectal cancer …

Colorectal cancer (CRC) is a typical cancer that accounts for 10% of all new cancer cases
annually and nearly 10% of all cancer deaths. Despite significant progress in current …

Lipid nanoparticles (LNPs) are the most clinically successful drug delivery systems that have
accelerated the development of mRNA drugs and vaccines. Among various structural …

While the World Health Organization (WHO) has de-escalated coronavirus disease 2019
(COVID-19) from a global health emergency, ongoing discussions persist as new viral …