Microglia states and nomenclature: A field at its crossroads
Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …
[HTML][HTML] Tissue-specific macrophages: how they develop and choreograph tissue biology
Macrophages are innate immune cells that form a 3D network in all our tissues, where they
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …
[PDF][PDF] Microglia: Immune and non-immune functions
K Borst, AA Dumas, M Prinz - Immunity, 2021 - cell.com
As resident macrophages of the central nervous system (CNS), microglia are associated
with diverse functions essential to the developing and adult brain during homeostasis and …
with diverse functions essential to the developing and adult brain during homeostasis and …
Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma
INTRODUCTION Myeloid cells are highly heterogeneous, with distinct ontogenies and
immune functions. The diverse role of myeloid populations, including monocytes …
immune functions. The diverse role of myeloid populations, including monocytes …
Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid
Macrophages are important players in the maintenance of tissue homeostasis. Perivascular
and leptomeningeal macrophages reside near the central nervous system (CNS) …
and leptomeningeal macrophages reside near the central nervous system (CNS) …
Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization
AR Pombo Antunes, I Scheyltjens, F Lodi… - Nature …, 2021 - nature.com
Glioblastomas are aggressive primary brain cancers that recur as therapy-resistant tumors.
Myeloid cells control glioblastoma malignancy, but their dynamics during disease …
Myeloid cells control glioblastoma malignancy, but their dynamics during disease …
Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders
INTRODUCTION The meninges are a three-layer membrane that covers the central nervous
system (CNS): The outermost layer, the dura mater, is attached onto the skull periosteum; …
system (CNS): The outermost layer, the dura mater, is attached onto the skull periosteum; …
[HTML][HTML] The neuroimmune axis of Alzheimer's disease
Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder with
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …
Specification of CNS macrophage subsets occurs postnatally in defined niches
All tissue-resident macrophages of the central nervous system (CNS)—including
parenchymal microglia, as well as CNS-associated macrophages (CAMs) such as …
parenchymal microglia, as well as CNS-associated macrophages (CAMs) such as …
Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine
Microglial function declines during aging. The interaction of microglia with the gut microbiota
has been well characterized during development and adulthood but not in aging. Here, we …
has been well characterized during development and adulthood but not in aging. Here, we …