Genetics of obsessive-compulsive disorder

B Mahjani, K Bey, J Boberg, C Burton - Psychological medicine, 2021 - cambridge.org
BackgroundObsessive-compulsive disorder (OCD) is a psychiatric disorder with multiple
symptom dimensions (eg contamination, symmetry). OCD clusters in families and decades …

Therapeutic potentials of ketamine and esketamine in obsessive–compulsive disorder (OCD), substance use disorders (SUD) and eating disorders (ED): a review of …

G Martinotti, S Chiappini, M Pettorruso, A Mosca… - Brain Sciences, 2021 - mdpi.com
The obsessive–compulsive spectrum refers to disorders drawn from several diagnostic
categories that share core features related to obsessive–compulsive disorder (OCD), such …

Obsessive‐compulsive disorder: etiology, neuropathology, and cognitive dysfunction

B Jalal, SR Chamberlain, BJ Sahakian - Brain and behavior, 2023 - Wiley Online Library
Background This review provides an overview of obsessive‐compulsive disorder (OCD)
symptoms, including the four partially distinct subtypes of the disorder, current diagnostic …

Neuroscientifically informed formulation and treatment planning for patients with obsessive-compulsive disorder: a review

DD Dougherty, BP Brennan, SE Stewart… - Jama …, 2018 - jamanetwork.com
Importance Obsessive-compulsive disorder (OCD) is a common and often debilitating
psychiatric illness. Recent advances in the understanding of the neuroscience of OCD have …

[HTML][HTML] Insulin and disorders of behavioural flexibility

M Sullivan, F Fernandez-Aranda… - Neuroscience & …, 2023 - Elsevier
Behavioural inflexibility is a symptom of neuropsychiatric and neurodegenerative disorders
such as Obsessive-Compulsive Disorder, Autism Spectrum Disorder and Alzheimer's …

Glutamatergic medications as adjunctive therapy for moderate to severe obsessive-compulsive disorder in adults: a systematic review and meta-analysis

F Hadi, S Kashefinejad, L Kamalzadeh… - BMC Pharmacology and …, 2021 - Springer
Background Obsessive-compulsive disorder (OCD) is among the most disabling
neuropsychiatric conditions characterized by the presence of repetitive intrusive thoughts …

Ketamine in the treatment of obsessive-compulsive disorder: a systematic review

ID Bandeira, DH Lins-Silva, VB Cavenaghi… - Harvard review of …, 2022 - journals.lww.com
Methods This systematic review aims to investigate the effects of ketamine in OCD, following
the Preferred Reporting Items for Systematic Review and Meta-analyses Protocols (PRISMA …

Anxiolytic effects of ascorbic acid and ketamine in mice

DB Fraga, G Olescowicz, M Moretti, A Siteneski… - Journal of Psychiatric …, 2018 - Elsevier
Some studies have demonstrated that ascorbic acid, similarly to ketamine, exhibits
antidepressant-like effects mediated, at least in part, by modulation of the glutamatergic …

The development of compulsive coping behaviour is associated with a downregulation of Arc in a Locus Coeruleus neuronal ensemble

C Velazquez-Sanchez, L Muresan… - …, 2023 - nature.com
Some compulsive disorders have been considered to stem from the loss of control over
coping strategies, such as displacement. However, the cellular mechanisms involved in the …

Investigational and experimental drugs to treat obsessive-compulsive disorder

G Grassi, C Cecchelli, L Vignozzi… - Journal of Experimental …, 2021 - Taylor & Francis
Abstract Treatment-resistance is a frequent condition for obsessive-compulsive disorder
(OCD). Over the past decades, a lot of effort has been made to address this issue, and …