Optogenetics at the presynapse
Optogenetic actuators enable highly precise spatiotemporal interrogation of biological
processes at levels ranging from the subcellular to cells, circuits and behaving organisms …
processes at levels ranging from the subcellular to cells, circuits and behaving organisms …
Pharmacology of adenosine receptors: the state of the art
Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …
How does adenosine control neuronal dysfunction and neurodegeneration?
RA Cunha - Journal of neurochemistry, 2016 - Wiley Online Library
The adenosine modulation system mostly operates through inhibitory A1 (A1R) and
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …
[HTML][HTML] Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice
Human astrocytes are larger and more complex than those of infraprimate mammals,
suggesting that their role in neural processing has expanded with evolution. To assess the …
suggesting that their role in neural processing has expanded with evolution. To assess the …
Efficient optogenetic silencing of neurotransmitter release with a mosquito rhodopsin
Information is carried between brain regions through neurotransmitter release from axonal
presynaptic terminals. Understanding the functional roles of defined neuronal projection …
presynaptic terminals. Understanding the functional roles of defined neuronal projection …
Receptors for purines and pyrimidines
V Ralevic, G Burnstock - Pharmacological reviews, 1998 - ASPET
Extracellular purines (adenosine, ADP, and ATP) and pyrimidines (UDP and UTP) are
important signaling molecules that mediate diverse biological effects via cellsurface …
important signaling molecules that mediate diverse biological effects via cellsurface …
The tripartite synapse: roles for gliotransmission in health and disease
In addition to being essential supporters of neuronal function, astrocytes are now recognized
as active elements in the brain. Astrocytes sense and integrate synaptic activity and …
as active elements in the brain. Astrocytes sense and integrate synaptic activity and …
[HTML][HTML] Adenosine receptors and brain diseases: neuroprotection and neurodegeneration
Adenosine acts in parallel as a neuromodulator and as a homeostatic modulator in the
central nervous system. Its neuromodulatory role relies on a balanced activation of inhibitory …
central nervous system. Its neuromodulatory role relies on a balanced activation of inhibitory …
Altered immune responses in mice lacking inducible nitric oxide synthase
NITRIC oxide (NO) is important in many biological functions1–5. It is generated from L-
arginine by the enzyme NO synthase (NOS). The cytokine-inducible NOS (iNOS) is activated …
arginine by the enzyme NO synthase (NOS). The cytokine-inducible NOS (iNOS) is activated …
[HTML][HTML] ATP and adenosine—Two players in the control of seizures and epilepsy development
Despite continuous advances in understanding the underlying pathogenesis of
hyperexcitable networks and lowered seizure thresholds, the treatment of epilepsy remains …
hyperexcitable networks and lowered seizure thresholds, the treatment of epilepsy remains …