Background Parkinson's disease (PD) is the second most prevalent neurodegenerative
disorder, characterized by motor and non-motor symptoms, significantly affecting patients' …

Protein aggregation is the main hallmark of neurodegenerative diseases. Many proteins
found in pathological inclusions are known to undergo liquid-liquid phase separation, a …

According to emerging studies, the excessive activation of microglia and the subsequent
release of pro-inflammatory cytokines play important roles in the pathogenesis and …

Parkinson's disease (PD) is a neurodegenerative disorder where alpha-synuclein plays a
central role in the death and dysfunction of neurons, both, in central, as well as in the …

Neuroinflammation and neurodegeneration often result from the aberrant deposition of
aggregated host proteins, including amyloid‐β, α‐synuclein, and prions, that can activate …

The mammalian CNS is an intricate and fragile structure, which on one hand is open to
change in order to store information, but on the other hand is vulnerable to damage from …

This review article provides an overview of the different species that α‐synuclein aggregates
can populate. It also attempts to reconcile conflicting views regarding the cytotoxic roles of …

Iron is essential for life. Many enzymes require iron for appropriate function. However,
dysregulation of intracellular iron homeostasis produces excessive reactive oxygen species …

Excessive activation of microglia and subsequent release of proinflammatory cytokines play
a crucial role in neuroinflammation and neurodegeneration in Parkinson's disease (PD) …

Protein misfolding is a general hallmark of protein deposition diseases, such as Alzheimer's
disease or Parkinson's disease, in which different types of aggregated species (oligomers …