The sensory, associative and limbic neocortical structures play a critical role in shaping
incoming noxious inputs to generate variable pain perceptions. Technological advances in …

The leading school of thought views fibromyalgia as a central sensitization syndrome.
Nociplastic pain is the recently proposed term to mechanistically explain central …

Background The adaption of brain region is fundamental to the development and
maintenance of nervous system disorders. The prelimbic cortex (PrL) participates in the …

Nociception is the neuronal process of encoding noxious stimuli and could be modulated at
peripheral, spinal, brainstem, and cortical levels. At cortical levels, several areas including …

Pain is a multifaceted process that encompasses unpleasant sensory and emotional
experiences. The essence of the pain process is aversion, or perceived negative emotion …

Previous human and rodent studies indicated that nociceptive stimuli activate many brain
regions that is involved in the somatosensory and emotional sensation. Although these …

Progress in bone fracture repair research has been made possible due to the development
of reproducible models of fracture in rodents with more clinically relevant fracture fixation …

Activation-induced manganese-enhanced MRI (AIM-MRI) is an attractive tool for non-
invasively mapping whole brain activities. Manganese ions (Mn2+) enter and accumulate in …