[HTML][HTML] The therapeutic potential of regulatory T cells: challenges and opportunities
F Bayati, M Mohammadi, M Valadi, S Jamshidi… - Frontiers in …, 2021 - frontiersin.org
Regulatory T cells (Tregs) are an immunosuppressive subgroup of CD4+ T cells which are
identified by the expression of forkhead box protein P3 (Foxp3). The modulation capacity of …
identified by the expression of forkhead box protein P3 (Foxp3). The modulation capacity of …
[HTML][HTML] CD4+CD25+ T regulatory cells in renal transplantation
J Cheung, B Zahorowska, M Suranyi… - Frontiers in …, 2022 - frontiersin.org
The immune response to an allograft activates lymphocytes with the capacity to cause
rejection. Activation of CD4+ CD25+ Foxp3+ T regulatory cells (Treg) can down-regulate …
rejection. Activation of CD4+ CD25+ Foxp3+ T regulatory cells (Treg) can down-regulate …
[HTML][HTML] A Phase I Clinical Trial with Ex Vivo Expanded Recipient Regulatory T cells in Living Donor Kidney Transplants
JM Mathew, J H.-Voss, A LeFever, I Konieczna… - Scientific reports, 2018 - nature.com
There is considerable interest in therapeutic transfer of regulatory T cells (Tregs) for
controlling aberrant immune responses. Initial clinical trials have shown the safety of Tregs …
controlling aberrant immune responses. Initial clinical trials have shown the safety of Tregs …
A case report of clonal EBV-like memory CD4+ T cell activation in fatal checkpoint inhibitor-induced encephalitis
DB Johnson, WJ McDonnell, PI Gonzalez-Ericsson… - Nature medicine, 2019 - nature.com
Checkpoint inhibitors produce durable responses in numerous metastatic cancers, but
immune-related adverse events (irAEs) complicate and limit their benefit. IrAEs can affect …
immune-related adverse events (irAEs) complicate and limit their benefit. IrAEs can affect …
[HTML][HTML] Antigen specificity enhances disease control by Tregs in vitiligo
Z Mukhatayev, ER Dellacecca, C Cosgrove… - Frontiers in …, 2020 - frontiersin.org
Vitiligo is an autoimmune skin disease characterized by melanocyte destruction. Regulatory
T cells (Tregs) are greatly reduced in vitiligo skin, and replenishing peripheral skin Tregs …
T cells (Tregs) are greatly reduced in vitiligo skin, and replenishing peripheral skin Tregs …
[HTML][HTML] Antigen specific regulatory T cells in kidney transplantation and other tolerance settings
Kidney transplantation is the most common solid organ transplant and the best current
therapy for end-stage kidney failure. However, with standard immunosuppression, most …
therapy for end-stage kidney failure. However, with standard immunosuppression, most …
[HTML][HTML] Regulatory T cells in atherosclerosis: is adoptive cell therapy possible?
AV Churov, YS Chegodaev, VA Khotina, VP Ofitserov… - Life, 2023 - mdpi.com
Simple Summary Atherosclerosis is a vascular disease with an asymptomatic debut and
development over decades. The mechanisms of progression of atherosclerosis are not …
development over decades. The mechanisms of progression of atherosclerosis are not …
[HTML][HTML] Linking the gut and liver: crosstalk between regulatory T cells and mucosa-associated invariant T cells
M Atif, S Warner, YH Oo - Hepatology International, 2018 - Springer
The gut–liver axis is increasingly considered to play a vital part in the progression of chronic
inflammatory gut and liver diseases. Hence, a detailed understanding of the local and …
inflammatory gut and liver diseases. Hence, a detailed understanding of the local and …
[HTML][HTML] Emerging therapeutic strategies to restore regulatory T cell control of islet autoimmunity in type 1 diabetes
V Volfson-Sedletsky, A Jones IV… - Frontiers in …, 2021 - frontiersin.org
Despite many decades of investigation uncovering the autoimmune mechanisms underlying
Type 1 Diabetes (T1D), translating these findings into effective therapeutics has proven …
Type 1 Diabetes (T1D), translating these findings into effective therapeutics has proven …
A clinical trial with adoptive transfer of ex vivo-induced, donor-specific immune-regulatory cells in kidney transplantation—a second report
I Koyama, H Bashuda, K Uchida, K Seino, S Habu… - …, 2020 - journals.lww.com
Background. Although the outcome of kidney transplantation (KTx) has improved, various
adverse effects of immunosuppressants and chronic rejection aggravate the long-term …
adverse effects of immunosuppressants and chronic rejection aggravate the long-term …