Regulatory T cells (Tregs) are an immunosuppressive subgroup of CD4+ T cells which are
identified by the expression of forkhead box protein P3 (Foxp3). The modulation capacity of …

The immune response to an allograft activates lymphocytes with the capacity to cause
rejection. Activation of CD4+ CD25+ Foxp3+ T regulatory cells (Treg) can down-regulate …

There is considerable interest in therapeutic transfer of regulatory T cells (Tregs) for
controlling aberrant immune responses. Initial clinical trials have shown the safety of Tregs …

Checkpoint inhibitors produce durable responses in numerous metastatic cancers, but
immune-related adverse events (irAEs) complicate and limit their benefit. IrAEs can affect …

Vitiligo is an autoimmune skin disease characterized by melanocyte destruction. Regulatory
T cells (Tregs) are greatly reduced in vitiligo skin, and replenishing peripheral skin Tregs …

Kidney transplantation is the most common solid organ transplant and the best current
therapy for end-stage kidney failure. However, with standard immunosuppression, most …

Simple Summary Atherosclerosis is a vascular disease with an asymptomatic debut and
development over decades. The mechanisms of progression of atherosclerosis are not …

The gut–liver axis is increasingly considered to play a vital part in the progression of chronic
inflammatory gut and liver diseases. Hence, a detailed understanding of the local and …

Despite many decades of investigation uncovering the autoimmune mechanisms underlying
Type 1 Diabetes (T1D), translating these findings into effective therapeutics has proven …

Background. Although the outcome of kidney transplantation (KTx) has improved, various
adverse effects of immunosuppressants and chronic rejection aggravate the long-term …