After exploring evolutionary aspects of branched-chain amino acid biosynthesis, the review
focuses on the extended leucine biosynthetic pathway as it operates in Saccharomyces …

The branched-chain amino acids are synthesized by plants, fungi and microorganisms, but
not by animals. Therefore, the enzymes of this pathway are potential target sites for the …

To determine the in vivo fluxes of the central metabolism we have developed a
comprehensive approach exclusively based on the fundamental enzyme reactions known to …

Geobacter sulfurreducens is one of the few microorganisms available in pure culture known
to directly accept electrons from a negatively poised electrode. Microarray analysis was …

The branched-chain amino acids (BCAAs [Ile, Leu, and Val]) represent important nutrients in
bacterial physiology, with roles that range from supporting protein synthesis to signaling and …

2007-01-15 Assigned to METANOMICS GMBH reassignment METANOMICS GMBH
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …

Using metabolic engineering, an efficient l-leucine production strain of Corynebacterium
glutamicum was developed. In the wild type of C. glutamicum, the leuA-encoded 2 …

Background Branched chain amino acids (BCAAs) are widely applied in the food,
pharmaceutical, and animal feed industries. Traditional chemical synthetic and enzymatic …

Mutants of Corynebacterium glutamicum were made and enzymatically characterized to
clone ilvD and ilvE, which encode dihydroxy acid dehydratase and transaminase B …

L-leucine is an essential amino acid widely used in food and pharmaceutical industries.
However, the relatively low production efficiency limits its large-scale application. In this …