[HTML][HTML] Phytochemicals involved in mitigating silent toxicity induced by heavy metals

J Ceramella, AC De Maio, G Basile, A Facente, E Scali… - Foods, 2024 - mdpi.com
Heavy metals (HMs) are natural elements present in the Earth's crust, characterised by a
high atomic mass and a density more than five times higher than water. Despite their origin …

Mitochondrial reactive oxygen species initiate gasdermin D-mediated pyroptosis and contribute to paraquat-induced nephrotoxicity

K Chen, M Li, Y Tang, Z Lu - Chemico-Biological Interactions, 2024 - Elsevier
Paraquat (PQ)-induced acute kidney injury (AKI) progresses rapidly and is associated with
high mortality rates; however, no specific antidote for PQ has been identified. Poor …

[HTML][HTML] Targeted UHPLC-MS analysis reveals disparate polyphenol composition and concentration in muscadine grape supplements with proportional antioxidant …

MC Chappell, AV Duncan, AC Melo, CL Schaich… - Antioxidants, 2022 - mdpi.com
Muscadine grape supplements (MGS) with high polyphenol content are a potential
therapeutic option to combat oxidative stress; however, the precise identity and …

[HTML][HTML] In Vitro Gastrointestinal Digestion Affects the Bioaccessibility of Bioactive Compounds in Hibiscus sabdariffa Beverages

JJ Rodríguez-Romero, A Arce-Reynoso… - Molecules, 2023 - mdpi.com
Hibiscus sabdariffa possess great versatility to be used as an ingredient for a whole range of
products with natural-based ingredients, which are growing in popularity due to the health …

[HTML][HTML] Pretreatment of ellagic acid protects ifosfamide-induced acute nephrotoxicity in rat kidneys: A mitochondrial, histopathological and oxidative stress …

M Shabani, D Bayrami, AA Moghadam, Z Jamali… - Toxicology Reports, 2023 - Elsevier
Ifosfamide (IFO) kidney damage is an important organ toxicity in children and adults
undergoing chemotherapy. Previous evidence has shown that IFO toxic metabolites such as …

Ellagic acid mitigates heat-induced testicular detriment in a mouse model

R Kumar, V Kumar, G Gurusubramanian… - The Journal of Steroid …, 2024 - Elsevier
Heat stress has been shown to have a detrimental impact on testicular activity and
spermatogenesis. Ellagic acid is a plant-derived organic compound that has a variety of …

Screening of Polyphenolic compounds to identify dual inhibitors against Glycogen Synthase 3β and Acetylcholinesterase for the treatment of Alzheimer's Diseases

M Arfeen, SS Alharbi, AN Alharbi - Research Journal of …, 2024 - indianjournals.com
Alzheimer's diseases is a neurodegenerative progressive diseases accompanied by
complex pathology. Because of its complex pathology, multi-target ligands are considered …

[HTML][HTML] The Green Synthesis of Reduced Graphene Oxide Using Ellagic Acid: Improving the Contrast-Enhancing Effect of Microbubbles in Ultrasound

Q Cheng, Y Wang, Q Zhou, S Duan, B Zhang, Y Li… - Molecules, 2023 - mdpi.com
There is an urgent need to realize precise clinical ultrasound with ultrasound contrast agents
that provide high echo intensity and mechanical index tolerance. Graphene derivatives …

[PDF][PDF] Interactions and mechanisms of phenolic compounds with human immunodeficiency virus-1 Tat protein

CMSD Santos, JAA Santos… - … Journal of Public …, 2024 - pdfs.semanticscholar.org
Human immunodeficiency virus remains a serious health threat, with an increase of 24%
newly cases globally. Targeting Tat protein is an emerging therapeutic strategy for inhibiting …

[HTML][HTML] Ellagic acid and cancer hallmarks: Insights from experimental evidence

M Čižmáriková, R Michalková, L Mirossay, G Mojžišová… - Biomolecules, 2023 - mdpi.com
Cancer is a complex and multifaceted disease with a high global incidence and mortality
rate. Although cancer therapy has evolved significantly over the years, numerous challenges …