The increase of many deadly diseases like infections by multidrug-resistant bacteria implies
re-inventing the wheel on drug discovery. A better comprehension of the metabolisms and …

Proper nucleosides availability is crucial for the proliferation of living entities (eukaryotic
cells, parasites, bacteria, and virus). Accordingly, the uses of inhibitors of the de novo …

A major cause of the paucity of new starting points for drug discovery is the lack of
interaction between academia and industry. Much of the global resource in biology is …

Malaria is one of the most significant causes of childhood mortality, but disease control
efforts are threatened by resistance of the Plasmodium parasite to current therapies …

Organic electrochemistry is concerned with the reduction and oxidation of organic molecules
at electrodes. Although it is now more than 200 years ago that the so-called Volta pile was …

Drug therapy is the mainstay of antimalarial therapy, yet current drugs are threatened by the
development of resistance. In an effort to identify new potential antimalarials, we have …

Drug discovery for neglected tropical diseases is carried out using both target-based and
phenotypic approaches. In this paper, target-based approaches are discussed, with a …

The flavoenzyme dihydroorotate dehydrogenase catalyzes the stereoselective oxidation of
(S)-dihydroorotate to orotate in the fourth of the six conserved enzymatic reactions involved …

The Malaria Drug Accelerator (MalDA) is a consortium of 15 leading scientific laboratories.
The aim of MalDA is to improve and accelerate the early antimalarial drug discovery process …

In current scenario, various heterocycles have come up exhibiting crucial role in various
medicinal agents which are valuable for mankind. Out of diverse range of heterocycle …