Fibrosis is characterized by the excessive extracellular matrix deposition due to
dysregulated wound and connective tissue repair response. Multiple organs can develop …

Microglia-mediated neuroinflammation is a common feature of neurodegenerative diseases
such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis …

The prevalence of obesity has reached pandemic proportions, and now approximately 25%
of adults in Westernized countries have obesity. Recognized as a major health concern …

Decades of work have elucidated cytokine signalling and transcriptional pathways that
control T cell differentiation and have led the way to targeted biologic therapies that are …

Non-alcoholic fatty liver disease (NAFLD) is a public health problem, affecting up to a third of
the world's adult population. Several cohort studies have consistently documented that …

Peroxisome proliferator-activated receptor (PPAR) α, β/δ, and γ modulate lipid homeostasis.
PPARα regulates lipid metabolism in the liver, the organ that largely controls whole-body …

The increasing epidemic of obesity worldwide is linked to serious health effects, including
increased prevalence of type 2 diabetes mellitus, cardiovascular disease and nonalcoholic …

Diabetes, a silent killer, is one of the most widely prevalent conditions of the present time.
According to the 2017 International Diabetes Federation (IDF) statistics, the global …

The midcycle surge of LH sets in motion interconnected networks of signaling cascades to
bring about rupture of the follicle and release of the oocyte during ovulation. Many mediators …

Metabolites produced by the host and microbiota play a crucial role in how human bodies
develop and remain healthy. Most of these metabolites are produced by microbiota and …