Polarized macrophages in periodontitis: characteristics, function, and molecular signaling

X Sun, J Gao, X Meng, X Lu, L Zhang… - Frontiers in …, 2021 - frontiersin.org
Periodontitis (PD) is a common chronic infectious disease. The local inflammatory response
in the host may cause the destruction of supporting periodontal tissue. Macrophages play a …

The role of transcription factors in shaping regulatory T cell identity

JL Trujillo-Ochoa, M Kazemian, B Afzali - Nature Reviews Immunology, 2023 - nature.com
Forkhead box protein 3-expressing (FOXP3+) regulatory T cells (Treg cells) suppress
conventional T cells and are essential for immunological tolerance. FOXP3, the master …

Inflammation and immune cell abnormalities in intracranial aneurysm subarachnoid hemorrhage (SAH): relevant signaling pathways and therapeutic strategies

J Jin, J Duan, L Du, W Xing, X Peng… - Frontiers in …, 2022 - frontiersin.org
Intracranial aneurysm subarachnoid hemorrhage (SAH) is a cerebrovascular disorder
associated with high overall mortality. Currently, the underlying mechanisms of pathological …

TGF‑β1: Gentlemanly orchestrator in idiopathic pulmonary fibrosis

Z Ye, Y Hu - International journal of molecular …, 2021 - spandidos-publications.com
Idiopathic pulmonary fibrosis (IPF) is a worldwide disease characterized by the chronic and
irreversible decline of lung function. Currently, there is no drug to successfully treat the …

[HTML][HTML] Microplastic consumption induces inflammatory signatures in the colon and prolongs a viral arthritis

DJ Rawle, T Dumenil, B Tang, CR Bishop, K Yan… - Science of the Total …, 2022 - Elsevier
Global microplastic (MP) contamination and the effects on the environment are well
described. However, the potential for MP consumption to affect human health remains …

Cellular miR-150-5p may have a crucial role to play in the biology of SARS-CoV-2 infection by regulating nsp10 gene

SM Akula, P Bolin, PP Cook - RNA biology, 2022 - Taylor & Francis
The role for circulating miRNAs as biomarkers of the COVID-19 disease remains uncertain.
We analysed the circulating miRNA profile in twelve COVID-19 patients with moderate …

Mycobacterium tuberculosis-macrophage interaction: Molecular updates

H Bo, UAE Moure, Y Yang, J Pan, L Li… - Frontiers in cellular …, 2023 - frontiersin.org
Mycobacterium tuberculosis (Mtb), the causative agent of Tuberculosis (TB), remains a
pathogen of great interest on a global scale. This airborne pathogen affects the lungs, where …

Regulation of the immune system by the insulin receptor in health and disease

P Makhijani, PJ Basso, YT Chan, N Chen… - Frontiers in …, 2023 - frontiersin.org
The signaling pathways downstream of the insulin receptor (InsR) are some of the most
evolutionarily conserved pathways that regulate organism longevity and metabolism. InsR …

The gut mucus network: A dynamic liaison between microbes and the immune system

R Inaba, S Vujakovic, K Bergstrom - Seminars in Immunology, 2023 - Elsevier
A complex mucus network made up of large polymers of the mucin-family glycoprotein
MUC2 exists between the large intestinal microbial mass and epithelial and immune cells …

Infectious triggers in periodontitis and the gut in rheumatoid arthritis (RA): A complex story about association and causality

B Möller, F Kollert, A Sculean, PM Villiger - Frontiers in immunology, 2020 - frontiersin.org
Rheumatoid arthritis (RA) is a systemic immune mediated inflammatory disease of unknown
origin, which is predominantly affecting the joints. Antibodies against citrullinated peptides …