[HTML][HTML] Mastoparans: a group of multifunctional α-helical peptides with promising therapeutic properties
Biologically active peptides have been attracting increasing attention, whether to improve
understanding of their mechanisms of action or in the search for new therapeutic drugs …
understanding of their mechanisms of action or in the search for new therapeutic drugs …
Syndecan receptors: pericellular regulators in development and inflammatory disease
The syndecans are the major family of transmembrane proteoglycans, usually bearing
multiple heparan sulfate chains. They are present on virtually all nucleated cells of …
multiple heparan sulfate chains. They are present on virtually all nucleated cells of …
Cationic antimicrobial peptides cytotoxicity on mammalian cells: an analysis using therapeutic index integrative concept
Antimicrobial peptides (AMPs) represent a class of molecules synthesized by different
organisms as an ancient innate defense mechanism against different pathogens like …
organisms as an ancient innate defense mechanism against different pathogens like …
[HTML][HTML] Selective amino acid substitution reduces cytotoxicity of the antimicrobial peptide mastoparan
LN Irazazabal, WF Porto, SM Ribeiro, S Casale… - … et Biophysica Acta (BBA …, 2016 - Elsevier
The emergence of antibiotic-resistant clinical isolates and the decreased rate of
development of new antibiotics are a constant threat to human health. In this context, the …
development of new antibiotics are a constant threat to human health. In this context, the …
Membrane permeability and antimicrobial peptides: Much more than just making a hole
JC Espeche, R Varas, P Maturana, AC Cutro… - Peptide …, 2024 - Wiley Online Library
Antimicrobial peptides (AMPs) are one of the elements of innate immunity that have a crucial
role in fighting infections. These molecules are produced by all kinds of cells and can …
role in fighting infections. These molecules are produced by all kinds of cells and can …
[HTML][HTML] Characterization of the Molecular Diversity and Degranulation Activity of Mastoparan Family Peptides from Wasp Venoms
X Ye, X Liu, X Luo, F Sun, C Qin, L Ding, W Zhu… - Toxins, 2023 - mdpi.com
Wasp stings have become an increasingly serious public health problem because of their
high incidence and mortality rates in various countries and regions. Mastoparan family …
high incidence and mortality rates in various countries and regions. Mastoparan family …
A helix-PXXP-helix peptide with antibacterial activity without cytotoxicity against MDRPA-infected mice
JK Lee, SC Park, KS Hahm, Y Park - Biomaterials, 2014 - Elsevier
In response to the growing problem of multidrug-resistant pathogenic microbes, much
attention is being paid to naturally occurring and synthetic antimicrobial peptides (AMPs) …
attention is being paid to naturally occurring and synthetic antimicrobial peptides (AMPs) …
Antibacterial activity of membrane-permeabilizing bactericidal cyclodextrin derivatives
H Yamamura, T Hagiwara, Y Hayashi, K Osawa… - ACS …, 2021 - ACS Publications
Antimicrobial peptides that act by disrupting bacterial membranes are attractive agents for
treating drug-resistant bacteria. This study investigates a membrane-disrupting peptide …
treating drug-resistant bacteria. This study investigates a membrane-disrupting peptide …
Mast cell degranulation by a hemolytic lipid toxin decreases GBS colonization and infection
C Gendrin, J Vornhagen, L Ngo, C Whidbey… - Science …, 2015 - science.org
Ascending infection of microbes from the lower genital tract into the amniotic cavity
increases the risk of preterm birth, stillbirth, and newborn infections. Host defenses that are …
increases the risk of preterm birth, stillbirth, and newborn infections. Host defenses that are …
Pro-necrotic activity of cationic mastoparan peptides in human glioblastoma multiforme cells via membranolytic action
AMB da Silva, LC Silva-Goncalves, FA Oliveira… - Molecular …, 2018 - Springer
Glioblastoma multiforme is the most common and lethal malignant brain tumor. Because of
its complexity and heterogeneity, this tumor has become resistant to conventional therapies …
its complexity and heterogeneity, this tumor has become resistant to conventional therapies …