[HTML][HTML] Mastoparans: a group of multifunctional α-helical peptides with promising therapeutic properties

CJC de Santana, OR Pires Júnior, W Fontes… - Frontiers in Molecular …, 2022 - frontiersin.org
Biologically active peptides have been attracting increasing attention, whether to improve
understanding of their mechanisms of action or in the search for new therapeutic drugs …

Syndecan receptors: pericellular regulators in development and inflammatory disease

S Gopal, S Arokiasamy, C Pataki… - Open …, 2021 - royalsocietypublishing.org
The syndecans are the major family of transmembrane proteoglycans, usually bearing
multiple heparan sulfate chains. They are present on virtually all nucleated cells of …

Cationic antimicrobial peptides cytotoxicity on mammalian cells: an analysis using therapeutic index integrative concept

M Bacalum, M Radu - International Journal of Peptide Research and …, 2015 - Springer
Antimicrobial peptides (AMPs) represent a class of molecules synthesized by different
organisms as an ancient innate defense mechanism against different pathogens like …

[HTML][HTML] Selective amino acid substitution reduces cytotoxicity of the antimicrobial peptide mastoparan

LN Irazazabal, WF Porto, SM Ribeiro, S Casale… - … et Biophysica Acta (BBA …, 2016 - Elsevier
The emergence of antibiotic-resistant clinical isolates and the decreased rate of
development of new antibiotics are a constant threat to human health. In this context, the …

Membrane permeability and antimicrobial peptides: Much more than just making a hole

JC Espeche, R Varas, P Maturana, AC Cutro… - Peptide …, 2024 - Wiley Online Library
Antimicrobial peptides (AMPs) are one of the elements of innate immunity that have a crucial
role in fighting infections. These molecules are produced by all kinds of cells and can …

[HTML][HTML] Characterization of the Molecular Diversity and Degranulation Activity of Mastoparan Family Peptides from Wasp Venoms

X Ye, X Liu, X Luo, F Sun, C Qin, L Ding, W Zhu… - Toxins, 2023 - mdpi.com
Wasp stings have become an increasingly serious public health problem because of their
high incidence and mortality rates in various countries and regions. Mastoparan family …

A helix-PXXP-helix peptide with antibacterial activity without cytotoxicity against MDRPA-infected mice

JK Lee, SC Park, KS Hahm, Y Park - Biomaterials, 2014 - Elsevier
In response to the growing problem of multidrug-resistant pathogenic microbes, much
attention is being paid to naturally occurring and synthetic antimicrobial peptides (AMPs) …

Antibacterial activity of membrane-permeabilizing bactericidal cyclodextrin derivatives

H Yamamura, T Hagiwara, Y Hayashi, K Osawa… - ACS …, 2021 - ACS Publications
Antimicrobial peptides that act by disrupting bacterial membranes are attractive agents for
treating drug-resistant bacteria. This study investigates a membrane-disrupting peptide …

Mast cell degranulation by a hemolytic lipid toxin decreases GBS colonization and infection

C Gendrin, J Vornhagen, L Ngo, C Whidbey… - Science …, 2015 - science.org
Ascending infection of microbes from the lower genital tract into the amniotic cavity
increases the risk of preterm birth, stillbirth, and newborn infections. Host defenses that are …

Pro-necrotic activity of cationic mastoparan peptides in human glioblastoma multiforme cells via membranolytic action

AMB da Silva, LC Silva-Goncalves, FA Oliveira… - Molecular …, 2018 - Springer
Glioblastoma multiforme is the most common and lethal malignant brain tumor. Because of
its complexity and heterogeneity, this tumor has become resistant to conventional therapies …