Specialized subpopulations of CD4+ T cells survey major histocompatibility complex class II–
peptide complexes to control phagosomal infections, help B cells, regulate tissue …

Aging is a physiological process mediated by numerous biological and genetic pathways,
which are directly linked to lifespan and are a driving force for all age-related diseases …

In chronic infections and in cancer, persistent antigen stimulation under suboptimal
conditions can lead to the induction of T-cell exhaustion. Exhausted T cells are …

Cytokines produced by T helper cells (T h cells) have essential roles in the body's defense
against viruses. Type 1 T helper (Th1) cells are essential for the host defense toward …

Autism spectrum disorder (ASD) is a group of complex multifactorial neurodevelopmental
disorders characterized by a wide and variable set of neuropsychiatric symptoms, including …

Tissue-resident memory T cells (TRM) represent a heterogeneous T cell population with the
functionality of both effector and memory T cells. TRM express residence gene signatures …

Upon activation, naïve CD4+ T helper (Th) cells differentiate into distinct Th effector cell
lineages depending on the local cytokine environment. However, these polarized Th cells …

Abstract CD4+ and CD8+ T lymphocytes mediate most of the adaptive immune response
against tumors. Naïve T lymphocytes specific for tumor antigens are primed in lymph nodes …

Tumor-infiltrating lymphocytes (TIL) often include a substantial subset of CD8+ tissue-
resident memory T (TRM) cells enriched in tumor-specific T cells. These TRM cells play a …

The fate of tissue-resident memory CD4 T cells (Trm) has been incompletely investigated.
Here we show that intranasal, but not parenteral, immunization with CTA1-3M2e-DD …