The biggest drawback of a current diabetes therapy is the treatment of the consequences not
the cause of the disease. Regardless of the diabetes type, preservation and recovery of …

During the past few decades, the science of toxicology has been undergoing a
transformation from observational to predictive science. New approach methodologies …

Introduction Toxicity data are unavailable for many thousands of chemicals in commerce
and the environment. Therefore, risk assessors need to rapidly screen these chemicals for …

Abstract Organ-on-chip (OoC) technology is full of engineering and biological challenges,
but it has the potential to revolutionize the Next-Generation Risk Assessment of novel …

Various sources of information can be used to better understand and predict compound
activity and safety-related endpoints, including biological data such as gene expression and …

Per-and polyfluoroalkyl substances (PFAS) are a group of xenobiotics that are widely
distributed throughout the aquatic environment. Many PFAS are possible thyroid hormone …

Marine mammals, due to their long life span, key position in the food web, and large lipid
deposits, often face significant health risks from accumulating contaminants. This systematic …

New approach methodologies (NAMs) that do not use experimental animals are, in certain
settings, entirely appropriate for assuring the safety of chemical ingredients, although …

Traditionally, chemical toxicity is determined by in vivo animal studies, which are low
throughput, expensive, and sometimes fail to predict compound toxicity in humans. Due to …

Perfluoroalkyl substances (PFAS) are persistent and pose a risk to human health. High
throughput screening (HTS) cell-based bioassays may inform risk assessment of PFAS …