Sialic acid–binding immunoglobulin-type lectins (Siglecs) are expressed on the majority of
white blood cells of the immune system and play critical roles in immune cell signaling …

Upregulation of sialyltransferases—the enzymes responsible for the addition of sialic acid to
growing glycoconjugate chains—and the resultant hypersialylation of up to 40–60% of …

Simple Summary All cells are covered in a thick layer of sugar molecules known as glycans.
Changes to this sugar coat are common in cancer, and in particular cancer cells often …

Simple Summary Sialylation is a post-translational modification that consists in the addition
of sialic acid to growing glycan chains on glycoproteins and glycolipids. Aberrant sialylation …

Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of
glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids play important …

A dense and diverse array of glycans on glycoproteins and glycolipids decorate all cell
surfaces. In vertebrates, many of these carry sialic acid, in a variety of linkages and glycan …

The sialic acid–binding immunoglobulin-like lectin (Siglec)–sialic acid immune axis is an
evolutionarily conserved immunoregulatory pathway that provides a mechanism for …

Siglecs (sialic acid–binding immunoglobulin-like lectins) are a family of receptors that bind
sialic acids in specific linkages on glycoproteins and glycolipids. Siglecs play roles in …

Immune cell-based therapies are a rapidly emerging class of new medicines that directly
treat and prevent targeted cancer. However multiple biological barriers impede the activity of …

The highly destructive mechanisms by which the immune system faces microbial infections
is under the control of a series of inhibitory receptors. While most of these receptors prevent …