Asthma is a complex inflammatory disease characterized by airway inflammation and
hyperresponsiveness. The mechanisms associated with the development and progression …

Epidemiological and challenge studies in healthy subjects and in individuals with asthma
highlight the health impact of environmental ozone even at levels considered safe. Acute …

A case-crossover study among 511,767 cardiovascular disease (CVD) deaths in Jiangsu
province, China, during 2015–2021 was conducted to assess the association of exposure to …

Background Sex differences in the incidence and prognosis of respiratory diseases have
been reported. Studies have shown that women are at increased risk of adverse health …

We have previously reported that the mouse gut microbiome contributes to pulmonary
responses to ozone, a common asthma trigger, and that short-chain fatty acids, end products …

Epidemiological data suggests increased prevalence of asthma in females than males,
suggesting a plausible role for sex-steroids, especially estrogen in the lungs. Estrogen …

Exposure to high levels of ozone contributes to insensitivity to glucocorticoids in asthma
treatment, but the underlying mechanisms are not known. We built two asthma models: a “T2 …

Sex differences clearly exist in incidence, susceptibility, and severity of airway disease and
in pulmonary responses to air pollutants such as ozone (O3). Prior rodent O3 exposure …

Emerging evidence suggests that sex differences exist in the control of lung innate immunity;
however, the specific roles of sex hormones in the inflammatory response, and the …

Chronic obstructive pulmonary disease (COPD) is a chronic lung disease characterised by
airway inflammation and progressive obstruction of the lung airflow. Current …