Metformin—mode of action and clinical implications for diabetes and cancer
I Pernicova, M Korbonits - Nature Reviews Endocrinology, 2014 - nature.com
Metformin has been the mainstay of therapy for diabetes mellitus for many years; however,
the mechanistic aspects of metformin action remained ill-defined. Recent advances revealed …
the mechanistic aspects of metformin action remained ill-defined. Recent advances revealed …
[HTML][HTML] The role of leptin/adiponectin ratio in metabolic syndrome and diabetes
P López-Jaramillo, D Gómez-Arbeláez… - … molecular biology and …, 2014 - degruyter.com
The metabolic syndrome comprises a cluster of cardiometabolic risk factors, with insulin
resistance and adiposity as its central features. Identifying individuals with metabolic …
resistance and adiposity as its central features. Identifying individuals with metabolic …
[HTML][HTML] Relationship between adiponectin, obesity and insulin resistance
GA Balsan, JLC Vieira, AM Oliveira… - Revista da Associação …, 2015 - SciELO Brasil
Objectives: the conditions of obesity and overweight pose a major risk for a number of
comorbidities, including clinical syndromes resulting from atherosclerotic disease. Recent …
comorbidities, including clinical syndromes resulting from atherosclerotic disease. Recent …
Acetyl-coenzyme A carboxylase: crucial metabolic enzyme and attractive target for drug discovery
L Tong - Cellular and Molecular Life Sciences CMLS, 2005 - Springer
Acetyl-coenzyme A carboxylases (ACCs) have crucial roles in fatty acid metabolism in most
living organisms. Mice deficient in ACC2 have continuous fatty acid oxidation and reduced …
living organisms. Mice deficient in ACC2 have continuous fatty acid oxidation and reduced …
Obesity and eye diseases
N Cheung, TY Wong - Survey of ophthalmology, 2007 - Elsevier
The prevalence of obesity has reached epidemic proportions in many countries. Although its
impact on overall health is well documented, less is known about the ocular manifestations …
impact on overall health is well documented, less is known about the ocular manifestations …
Omentin: a novel link between inflammation, diabesity, and cardiovascular disease
BK Tan, R Adya, HS Randeva - Trends in cardiovascular medicine, 2010 - Elsevier
Obesity has reached pandemic proportions and is associated with serious cardiometabolic
sequealae including insulin resistance, diabetes, dyslipidemia, hypertension, and …
sequealae including insulin resistance, diabetes, dyslipidemia, hypertension, and …
[HTML][HTML] The development of porcine models of obesity and the metabolic syndrome
ME Spurlock, NK Gabler - The Journal of nutrition, 2008 - Elsevier
Despite aggressive research aimed at understanding the myriad biochemical factors that are
integrated to balance energy intake and expenditure to maintain normal body weight …
integrated to balance energy intake and expenditure to maintain normal body weight …
Circulating levels of leptin, adiponectin, resistin, and ghrelin in inflammatory bowel disease
K Karmiris, IE Koutroubakis, C Xidakis… - Inflammatory bowel …, 2006 - academic.oup.com
Background There is evidence that adipocytokines play an important role in metabolism and
in inflammation. Because human metabolism dramatically changes in inflammatory bowel …
in inflammation. Because human metabolism dramatically changes in inflammatory bowel …
Adipose tissue and reproductive health
H Mathew, VD Castracane, C Mantzoros - Metabolism, 2018 - Elsevier
The understanding of adipose tissue role has evolved from that of a depot energy storage
organ to a dynamic endocrine organ. While genetics, sexual phenotype and sex steroids …
organ to a dynamic endocrine organ. While genetics, sexual phenotype and sex steroids …
PPARγ-activating angiotensin type-1 receptor blockers induce adiponectin
R Clasen, M Schupp, A Foryst-Ludwig, C Sprang… - …, 2005 - Am Heart Assoc
The adipose-specific protein adiponectin has been recently discovered to improve insulin
sensitivity. Angiotensin type-1 receptor (AT1R) blockers (ARBs) reduce the incidence of type …
sensitivity. Angiotensin type-1 receptor (AT1R) blockers (ARBs) reduce the incidence of type …