Metformin has been the mainstay of therapy for diabetes mellitus for many years; however,
the mechanistic aspects of metformin action remained ill-defined. Recent advances revealed …

The metabolic syndrome comprises a cluster of cardiometabolic risk factors, with insulin
resistance and adiposity as its central features. Identifying individuals with metabolic …

Objectives: the conditions of obesity and overweight pose a major risk for a number of
comorbidities, including clinical syndromes resulting from atherosclerotic disease. Recent …

Acetyl-coenzyme A carboxylases (ACCs) have crucial roles in fatty acid metabolism in most
living organisms. Mice deficient in ACC2 have continuous fatty acid oxidation and reduced …

The prevalence of obesity has reached epidemic proportions in many countries. Although its
impact on overall health is well documented, less is known about the ocular manifestations …

Obesity has reached pandemic proportions and is associated with serious cardiometabolic
sequealae including insulin resistance, diabetes, dyslipidemia, hypertension, and …

Despite aggressive research aimed at understanding the myriad biochemical factors that are
integrated to balance energy intake and expenditure to maintain normal body weight …

Background There is evidence that adipocytokines play an important role in metabolism and
in inflammation. Because human metabolism dramatically changes in inflammatory bowel …

The understanding of adipose tissue role has evolved from that of a depot energy storage
organ to a dynamic endocrine organ. While genetics, sexual phenotype and sex steroids …

The adipose-specific protein adiponectin has been recently discovered to improve insulin
sensitivity. Angiotensin type-1 receptor (AT1R) blockers (ARBs) reduce the incidence of type …