The ketone bodies acetoacetate (AcAc) and β-hydroxybutyrate (βHB) have pleiotropic
effects in multiple organs including brain, heart, and skeletal muscle by serving as an …

Cerebral metabolic dysfunction is a critical pathological hallmark observed in the aftermath
of traumatic brain injury (TBI), as extensively documented in clinical investigations and …

Mitochondrial dysfunction and the use of alternative energy substrates are potential
therapeutic targets, but improved understanding of the causes, impact and significance of …

Migraines display atypical age dependence, as the peak of their prevalence occurs between
the ages of 20–40 years. With age, headache attacks occur less frequently and are …

Traumatic brain injuries (TBIs) constitute a significant public health issue and a major source
of disability and death in the United States and worldwide. TBIs are strongly associated with …

Background Traumatic brain injury (TBI) and spinal cord injury (SCI) are acquired injuries to
the central nervous system (CNS) caused by external forces that cause temporary or …

BHB offers potential therapeutic advantages in the comprehensive approach to improve
outcomes for TBI patients. However, careful consideration of safety and efficacy is essential …

Metabolomic biomarkers hold promise in aiding the diagnosis and prognostication of
traumatic brain injury. In Canada, over 165,000 individuals annually suffer from a traumatic …

Glucose is the primary energy source for neural stem cells (NSCs), supporting their
proliferation, differentiation, and quiescence. However, the high demand for glucose during …

In fact, the C-MAC D-Blade performed better than the GlideScope in our set of included
studies, although not reaching statistical significance for six out of the seven evaluated …