Heat shock proteins (HSPs) constitute a large family of proteins involved in protein folding
and maturation whose expression is induced by heat shock or other stressors. The major …

Heat shock proteins (HSPs) are a large family of chaperones that are involved in protein
folding and maturation of a variety of “client” proteins protecting them from degradation …

Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in childhood. Here we
studied 60 RMSs using whole-exome/-transcriptome sequencing, copy number (CN) and …

Emerging evidence indicates that DNA methylation plays an important role in the initiation
and progression of nasopharyngeal carcinoma (NPC). DNAJA4 is hypermethylated in NPC …

Tumor classification has evolved over the last decades with technical progress contributing
much to our current concepts. Among diagnostic hallmarks, novelties were immunostaining …

Undifferentiated solid tumors with small blue round cell histology and expression of CD99
mostly resemble Ewing sarcoma. However, they also may include other tumors such as …

Rhabdomyosarcoma is the most common soft-tissue sarcoma of childhood, and despite
clinical advances, subsets of these patients continue to suffer high levels of morbidity and …

Background High-grade soft tissue sarcomas are a heterogeneous, complex group of
aggressive malignant tumors showing mesenchymal differentiation. Recently, soft tissue …

To elucidate the mechanisms underlying the divergent clinicopathologic spectrum of
EWSR1/FUS:: CREB translocation-associated tumors, we performed a comprehensive …

Using a candidate gene approach we recently identified frequent methylation of the RASSF2
gene associated with poor overall survival in Ewing sarcoma (ES). To identify effective …