[HTML][HTML] Insights from transgenic mouse models of PyMT-induced breast cancer: recapitulating human breast cancer progression in vivo
Breast cancer is associated with the second highest cancer-associated deaths worldwide.
Therefore, understanding the key events that determine breast cancer progression …
Therefore, understanding the key events that determine breast cancer progression …
[HTML][HTML] Tumor-associated macrophages: critical players in drug resistance of breast cancer
M Xiao, J He, L Yin, X Chen, X Zu, Y Shen - Frontiers in Immunology, 2021 - frontiersin.org
Drug resistance is one of the most critical challenges in breast cancer (BC) treatment. The
occurrence and development of drug resistance are closely related to the tumor immune …
occurrence and development of drug resistance are closely related to the tumor immune …
Targeting tumor‐associated macrophages: A potential treatment for solid tumors
Y Chen, H Jin, Y Song, T Huang, J Cao… - Journal of Cellular …, 2021 - Wiley Online Library
Tumor‐associated macrophages (TAMs) in solid tumors exert protumor activities by
releasing cytokines or growth factors into the tumor microenvironment. Increasing studies …
releasing cytokines or growth factors into the tumor microenvironment. Increasing studies …
A DNA hypomethylating drug alters the tumor microenvironment and improves the effectiveness of immune checkpoint inhibitors in a mouse model of pancreatic …
Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer that has proven refractory to
immunotherapy. Previously, treatment with the DNA hypomethylating drug decitabine (5-aza …
immunotherapy. Previously, treatment with the DNA hypomethylating drug decitabine (5-aza …
[HTML][HTML] MSP-RON pathway: potential regulator of inflammation and innate immunity
L Huang, X Fang, D Shi, S Yao, W Wu, Q Fang… - Frontiers in …, 2020 - frontiersin.org
Macrophage-stimulating protein (MSP), a soluble protein mainly synthesized by the liver, is
the only known ligand for recepteur d'origine nantais (RON), which is a member of the MET …
the only known ligand for recepteur d'origine nantais (RON), which is a member of the MET …
Targeting isoforms of RON kinase (MST1R) drives antitumor efficacy
J Kim, DI Koh, M Lee, YS Park, SW Hong… - Cell Death & …, 2023 - nature.com
Recepteur d'origine nantais (RON, MST1R) is a single-span transmembrane receptor
tyrosine kinase (RTK) aberrantly expressed in numerous cancers, including various solid …
tyrosine kinase (RTK) aberrantly expressed in numerous cancers, including various solid …
Translation of cancer immunotherapy from the bench to the bedside
The tremendous success of immune checkpoint blockades has revolutionized cancer
management. Our increased understanding of the cell types that compose the tumor …
management. Our increased understanding of the cell types that compose the tumor …
[HTML][HTML] Tailoring therapies to counter the divergent immune landscapes of breast cancer
Breast cancer remains a significant clinical concern affecting millions of women worldwide.
Immunotherapy is a rapidly growing drug class that has revolutionized cancer treatment but …
Immunotherapy is a rapidly growing drug class that has revolutionized cancer treatment but …
[HTML][HTML] An introduction and overview of RON receptor tyrosine kinase signaling
RON is a receptor tyrosine kinase (RTK) of the MET receptor family that is canonically
involved in mediating growth and inflammatory signaling. RON is expressed at low levels in …
involved in mediating growth and inflammatory signaling. RON is expressed at low levels in …
The MSP‐RON axis stimulates cancer cell growth in models of triple negative breast cancer
R Millar, A Kilbey, SJ Remak, TM Severson… - Molecular …, 2020 - Wiley Online Library
Triple‐negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with
poor prognosis and high rates of relapse. The lack of actionable targets for TNBC has …
poor prognosis and high rates of relapse. The lack of actionable targets for TNBC has …