FUS mutant human motoneurons display altered transcriptome and microRNA pathways with implications for ALS pathogenesis
The FUS gene has been linked to amyotrophic lateral sclerosis (ALS). FUS is a ubiquitous
RNA-binding protein, and the mechanisms leading to selective motoneuron loss …
RNA-binding protein, and the mechanisms leading to selective motoneuron loss …
MicroRNA profiling reveals marker of motor neuron disease in ALS models
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder marked by
the loss of motor neurons (MNs) in the brain and spinal cord, leading to fatally debilitating …
the loss of motor neurons (MNs) in the brain and spinal cord, leading to fatally debilitating …
A new perspective on depression and neuroinflammation: Non-coding RNA
S Zhou, R Chen, Y She, X Liu, H Zhao, C Li… - Journal of psychiatric …, 2022 - Elsevier
The high incidence and relapse rate of depression, as well comorbidity with other diseases,
has made depression one of the primary causes of years of life lived with disability …
has made depression one of the primary causes of years of life lived with disability …
Role of microRNA in proliferation phase of wound healing
Wound healing is a complex biological process that is generally composed of four phases:
hemostasis, inflammation, proliferation, and remodeling. The proliferation phase is crucial …
hemostasis, inflammation, proliferation, and remodeling. The proliferation phase is crucial …
Prediction of potential miRNA–disease associations through a novel unsupervised deep learning framework with variational autoencoder
The important role of microRNAs (miRNAs) in the formation, development, diagnosis, and
treatment of diseases has attracted much attention among researchers recently. In this study …
treatment of diseases has attracted much attention among researchers recently. In this study …
Role of extracellular vesicles in amyotrophic lateral sclerosis
D Ferrara, L Pasetto, V Bonetto, M Basso - Frontiers in neuroscience, 2018 - frontiersin.org
Amyotrophic Lateral Sclerosis (ALS) is the most common motor neuron disease in adults
and primarily targets upper and lower motor neurons. The progression of the disease is …
and primarily targets upper and lower motor neurons. The progression of the disease is …
Motor neuron-derived microRNAs cause astrocyte dysfunction in amyotrophic lateral sclerosis
We recently demonstrated that microRNA-218 (miR-218) is greatly enriched in motor
neurons and is released extracellularly in amyotrophic lateral sclerosis model rats. To …
neurons and is released extracellularly in amyotrophic lateral sclerosis model rats. To …
[HTML][HTML] Antagonizing miR-218-5p attenuates Wnt signaling and reduces metastatic bone disease of triple negative breast cancer cells
H Taipaleenmäki, NH Farina, AJ van Wijnen, JL Stein… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Wnt signaling is implicated in bone formation and activated in breast cancer cells promoting
primary and metastatic tumor growth. A compelling question is whether osteogenic miRNAs …
primary and metastatic tumor growth. A compelling question is whether osteogenic miRNAs …
[HTML][HTML] Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity
LF Martins, I Brambilla, A Motta, S de Pretis, GP Bhat… - Neuron, 2022 - cell.com
The nervous system requires metabolites and oxygen supplied by the neurovascular
network, but this necessitates close apposition of neurons and endothelial cells. We find …
network, but this necessitates close apposition of neurons and endothelial cells. We find …
miR-218 promotes dopaminergic differentiation and controls neuron excitability and neurotransmitter release through the regulation of a synaptic-related genes …
S Pulcrano, R De Gregorio, C De Sanctis… - Journal of …, 2023 - Soc Neuroscience
In the brain, microRNAs (miRNAs) are believed to play a role in orchestrating synaptic
plasticity at a higher level by acting as an additional mechanism of translational regulation …
plasticity at a higher level by acting as an additional mechanism of translational regulation …