[HTML][HTML] MicroRNAs instruct and maintain cell type diversity in the nervous system

N Zolboot, JX Du, F Zampa, G Lippi - Frontiers in Molecular …, 2021 - frontiersin.org
Characterizing the diverse cell types that make up the nervous system is essential for
understanding how the nervous system is structured and ultimately how it functions. The …

[HTML][HTML] Upregulation of β-catenin due to loss of miR-139 contributes to motor neuron death in amyotrophic lateral sclerosis

S Hawkins, SC Namboori, A Tariq, C Blaker… - Stem Cell Reports, 2022 - cell.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the loss of motor neurons (MNs). There are no effective treatments and patients usually die …

MicroRNA metabolism and dysregulation in amyotrophic lateral sclerosis

P Rinchetti, M Rizzuti, I Faravelli, S Corti - Molecular neurobiology, 2018 - Springer
MicroRNAs (miRNAs) are a subset of endogenous, small, non-coding RNA molecules
involved in the post-transcriptional regulation of eukaryotic gene expression. Dysregulation …

[HTML][HTML] A hidden threshold in motor neuron gene networks revealed by modulation of miR-218 dose

ND Amin, G Senturk, G Costaguta, S Driscoll… - Neuron, 2021 - cell.com
Disruption of homeostatic microRNA (miRNA) expression levels is known to cause human
neuropathology. However, the gene regulatory and phenotypic effects of altering a miRNA's …

[HTML][HTML] Emerging potential of exosomal non-coding RNA in parkinson's disease: a review

P Zhang, M Rasheed, J Liang, C Wang… - Frontiers in Aging …, 2022 - frontiersin.org
Exosomes are extracellular vesicles that are released by cells and circulate freely in body
fluids. Under physiological and pathological conditions, they serve as cargo for various …

[HTML][HTML] Human circular RNA‑0054633 regulates high glucose‑induced vascular endothelial cell dysfunction through the microRNA‑218/roundabout 1 and microRNA …

L Pan, W Lian, X Zhang, S Han… - International …, 2018 - spandidos-publications.com
The aim of the present study was to investigate the relative regulation of human circular RNA‑
0054633 (hsa_circ_0054633), microRNA‑218 (miR‑218), roundabout 1 (ROBO1) and heme …

MicroRNA regulation of prefrontal cortex development and psychiatric risk in adolescence

A Morgunova, C Flores - Seminars in cell & developmental biology, 2021 - Elsevier
In this review, we examine the role of microRNAs in the development of the prefrontal cortex
(PFC) in adolescence and in individual differences in vulnerability to mental illness. We …

[HTML][HTML] Neurotransmitter switching regulated by miRNAs controls changes in social preference

D Dulcis, G Lippi, CJ Stark, LH Do, DK Berg… - Neuron, 2017 - cell.com
Changes in social preference of amphibian larvae result from sustained exposure to kinship
odorants. To understand the molecular and cellular mechanisms of this neuroplasticity, we …

[HTML][HTML] miR-34b/c regulates Wnt1 and enhances mesencephalic dopaminergic neuron differentiation

R De Gregorio, S Pulcrano, C De Sanctis, F Volpicelli… - Stem Cell Reports, 2018 - cell.com
The differentiation of dopaminergic neurons requires concerted action of morphogens and
transcription factors acting in a precise and well-defined time window. Very little is known …

Up‐regulated miR‐192‐5p expression rescues cognitive impairment and restores neural function in mice with depression via the Fbln2‐mediated TGF‐β1 signaling …

CZ Tang, JT Yang, QH Liu, YR Wang… - The FASEB …, 2019 - Wiley Online Library
Depression represents a condition characterized by cognitive deficits and neural dysfunction
and has recently been correlated with microRNAs (miRs) and their respective target genes …