Spinal muscular atrophy is caused by deletions or mutations in the SMN1 gene that result in
reduced expression of the SMN protein. The SMN protein is an essential molecular …

Spinal muscular atrophy (SMA), a leading genetic cause of infant death, is a
neurodegenerative disease characterized by the selective loss of particular groups of motor …

Genome-wide functional screening using the CRISPR-Cas9 system is a powerful tool to
uncover tumor-specific and common genetic dependencies across cancer cell lines. Current …

Abstract microRNAs (miRNAs) play a crucial role in brain growth and function. Hence,
research on miRNA has the potential to reveal much about the etiology of neuropsychiatric …

Neuromuscular junction (NMJ) formation involves morphological changes both in motor
terminals and muscle membrane. The molecular mechanisms leading to NMJ formation and …

Spinal motor neurons deficiency results in a series of devastating disorders such as
amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA) and spinal cord injury …

Dgcr8 knockout cells provide a great means to understand the function of microRNAs
(miRNAs) in vitro and in vivo. Current strategies to study miRNA function in Dgcr8 knockout …

MicroRNAs (miRNAs) modulate mRNA expression, and their deregulation contributes to
various diseases including amyotrophic lateral sclerosis (ALS). As fused in sarcoma (FUS) is …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that primarily targets
motor neurons. Motor neurons from ALS patients show cytoplasmic inclusions that are …

Abstract microRNA-dependent post-transcriptional control represents an important gene-
regulatory layer in post-mitotic neuronal development and synaptic plasticity. We recently …