Gout is well known as an inflammatory rheumatic disease presenting with arthritis and
abnormal metabolism of uric acid. The recognition of diet-induced systemic metabolic …

Ageing is a complex trait controlled by genes and the environment. The highly conserved
mechanistic target of rapamycin signalling pathway (mTOR) is a major regulator of lifespan …

The peptide hormone insulin is a key regulator of energy metabolism, proliferation and
survival. Binding of insulin to its receptor activates the PI3K/AKT signalling pathway, which …

Brain function relies almost solely on glucose as an energy substrate. The main model of
brain metabolism proposes that glucose is taken up and converted into lactate by astrocytes …

The organs and metabolic pathways involved in energy metabolism, and the process of ATP
production from nutrients, are comparable between humans and Drosophila melanogaster …

There has been rapid growth in the use of Drosophila and other invertebrate systems to
dissect mechanisms governing metabolism. New assays and approaches to physiology …

Metabolic stress caused by excess nutrients accelerates aging. We recently demonstrated
that the newly discovered enzyme glycerol-3-phosphate phosphatase (G3PP; gene Pgp) …

Chronic sleep loss profoundly impacts metabolic health and shortens lifespan, but studies of
the mechanisms involved have focused largely on acute sleep deprivation. 1, 2 To identify …

Tumor-induced host wasting and mortality are general phenomena across species. Many
groups have previously demonstrated endocrinal impacts of malignant tumors on host …

Abstract System-wide metabolic homeostasis is crucial for maintaining physiological
functions of living organisms. Stable-isotope tracing metabolomics allows to unravel …