The so-called amyloid hypothesis, that the accumulation and deposition of oligomeric or
fibrillar amyloid β (Aβ) peptide is the primary cause of Alzheimer's disease (AD), has been …

Alzheimer's disease (AD) is a prevalently found tauopathy characterized by memory loss
and cognitive insufficiency. AD is an age-related neurodegenerative disease with two major …

Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …

Microglia are brain resident macrophages originated from primitive progenitor cells in the
yolk sac. Microglia can be activated within hours and recruited to the lesion site …

The development of α‐synuclein immunoreactive aggregates in selectively vulnerable
neuronal types of the human central, peripheral, and enteric nervous systems is crucial for …

Reactive oxygen species are constantly produced in aerobic organisms as by-products of
normal oxygen metabolism and include free radicals such as superoxide anion (O 2−) and …

The kinesin, dynein, and myosin superfamily molecular motors have fundamental roles in
neuronal function, plasticity, morphogenesis, and survival by transporting cargos such as …

To date, there have been few systematic attempts to provide a standard operating procedure
for the neuropathological diagnosis of Parkinson's disease (PD). Pathological examination …

Filamentous tau inclusions are hallmarks of Alzheimer's disease (AD) and related
tauopathies, but earlier pathologies may herald disease onset. To investigate this, we …

Advances in our understanding of the mechanisms of tau-mediated neurodegeneration in
Alzheimer's disease (AD) and related tauopathies, which are characterized by prominent …