Ezetimibe therapy: mechanism of action and clinical update

BAP Phan, TD Dayspring, PP Toth - Vascular health and risk …, 2012 - Taylor & Francis
The lowering of low-density lipoprotein cholesterol (LDL-C) is the primary target of therapy in
the primary and secondary prevention of cardiovascular events. Although statin therapy is …

Combination therapy in dyslipidemia: where are we now?

AL Catapano, M Farnier, JAM Foody, PP Toth… - Atherosclerosis, 2014 - Elsevier
Lowering low-density lipoprotein cholesterol (LDL-C) reduces the risk of cardiovascular
disease: each 1.0 mmol/L (38.7 mg/dL) reduction in LDL-C reduces the incidence of major …

Ezetimibe and improving cardiovascular outcomes: current evidence and perspectives

A Pradhan, M Bhandari, R Sethi - Cardiology Research and …, 2020 - Wiley Online Library
Low‐density lipoprotein lowering with statins has convincingly and consistently proven to
reduce cardiovascular events in both primary and secondary prevention. However, despite …

Drug treatment of hyperlipidaemia: a guide to the rational use of lipid-lowering drugs

PP Toth - Drugs, 2010 - Springer
Mammalian sterol and lipid metabolism depends on a large number of highly evolved
biochemical and histological processes responsible for the absorption, distribution and …

Ezetimibe therapy for dyslipidemia: an update

N Katsiki, E Theocharidou… - Current …, 2013 - ingentaconnect.com
Ezetimibe, an inhibitor of intestinal cholesterol absorption, can decrease total cholesterol
(TC), low density lipoprotein cholesterol (LDL-C), triglycerides (TGs) and apolipoprotein …

[PDF][PDF] Facts and ideas from anywhere

WC Roberts - Baylor University Medical Center Proceedings, 2006 - Taylor & Francis
Baylor University Medical Center Proceedings Volume 19, Number 1 74 that pertains to
medicine, consider the virtues of taciturnity. Look out. Speak only when you have something …

Update on the efficacy and safety of combination ezetimibe plus statin therapy

PP Toth, A Catapano, JE Tomassini… - Clinical …, 2010 - Taylor & Francis
The primary aim of lipid-related cardiovascular disease (CVD) risk management is the
lowering of LDL-C levels. Numerous studies have shown that statins, which inhibit …

IMPROVE-IT: what have we learned?

M Banach, D Nikolic, M Rizzo… - Current Opinion in …, 2016 - journals.lww.com
Ezetimibe/simvastatin combination, either as a single pill or as the combined use of the
individual compounds, represents a well-tolerated and efficacious choice for dyslipidemia …

The efficacy and safety of ezetimibe coadministered with statin therapy in various patient groups

A Catapano, PP Toth, JE Tomassini… - Clinical …, 2013 - Taylor & Francis
Various guidelines for cholesterol management recognize LDL cholesterol (LDL‑C) lowering
as the primary target of lipid‑lowering therapy (LLT) and statin therapy as an important …

Statin combination therapy and cardiovascular risk reduction

PP Toth, M Farnier, JE Tomassini, JAM Foody… - Future …, 2016 - Future Medicine
In numerous clinical trials, lowering LDL-C with statin therapy has been demonstrated to
reduce the risk of cardiovascular disease (CVD) in primary and secondary prevention …