Base excision repair in physiology and pathology of the central nervous system
M Bosshard, E Markkanen, B Van Loon - International journal of …, 2012 - mdpi.com
Relatively low levels of antioxidant enzymes and high oxygen metabolism result in formation
of numerous oxidized DNA lesions in the tissues of the central nervous system …
of numerous oxidized DNA lesions in the tissues of the central nervous system …
[HTML][HTML] 2, 3, 5, 4'-tetrahydroxystilbene-2-O-beta-D-glucoside protects against neuronal cell death and traumatic brain injury-induced pathophysiology
YH Chen, YC Chen, YT Chin, CC Wang… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
Traumatic brain injury (TBI) is a global health issue that affects at least 10 million people per
year. Neuronal cell death and brain injury after TBI, including apoptosis, inflammation, and …
year. Neuronal cell death and brain injury after TBI, including apoptosis, inflammation, and …
[HTML][HTML] Additional functions of selected proteins involved in DNA repair
V Koliadenko, T Wilanowski - Free Radical Biology and Medicine, 2020 - Elsevier
Protein moonlighting is a phenomenon in which a single polypeptide chain can perform a
number of different unrelated functions. Here we present our analysis of moonlighting in the …
number of different unrelated functions. Here we present our analysis of moonlighting in the …
Up-regulation of GBP2 is associated with neuronal apoptosis in rat brain cortex following traumatic brain injury
Q Miao, M Ge, L Huang - Neurochemical research, 2017 - Springer
Abstract Guanylate binding protein 2 (GBP2) is one member of GBP family. Recently, GBP2
has been proposed to be a novel target of anti-cancer drugs. However, the role of GBP2 in …
has been proposed to be a novel target of anti-cancer drugs. However, the role of GBP2 in …
Direct hippocampal injection of pseudo lentivirus-delivered nerve growth factor gene rescues the damaged cognitive function after traumatic brain injury in the rat
Y Lin, J Wan, G Gao, Y Pan, S Ding, Y Fan, Y Wang… - Biomaterials, 2015 - Elsevier
Traumatic brain injury (TBI) treatment is a long-term process and requires repeated
medicine administration, which, however, can cause high expense, infection, and …
medicine administration, which, however, can cause high expense, infection, and …
Motor deficits are triggered by reperfusion-reoxygenation injury as diagnosed by MRI and by a mechanism involving oxidants
A Drobyshevsky, K Luo, M Derrick, L Yu… - Journal of …, 2012 - Soc Neuroscience
The early antecedents of cerebral palsy (CP) are unknown but are suspected to be due to
hypoxia-ischemia (HI). In our rabbit model of CP, the MRI biomarker, apparent diffusion …
hypoxia-ischemia (HI). In our rabbit model of CP, the MRI biomarker, apparent diffusion …
The nitrone free radical scavenger NXY-059 is neuroprotective when administered after traumatic brain injury in the rat
F Clausen, N Marklund, A Lewén… - Journal of Neurotrauma, 2008 - liebertpub.com
Reactive oxygen species (ROS) are important contributors to the secondary injury cascade
following traumatic brain injury (TBI), and ROS inhibition has consistently been shown to be …
following traumatic brain injury (TBI), and ROS inhibition has consistently been shown to be …
Assessment of traumatic brain injury by increased 64Cu uptake on 64CuCl2 PET/CT
Copper is a nutritional trace element required for cell proliferation and wound repair.
Methods: To explore increased copper uptake as a biomarker for noninvasive assessment of …
Methods: To explore increased copper uptake as a biomarker for noninvasive assessment of …
The anti-inflammatory role of extranuclear apurinic/apyrimidinic endonuclease 1/redox effector factor-1 in reactive astrocytes
H Baek, CS Lim, HS Byun, HS Cho, YR Lee, YS Shin… - Molecular brain, 2016 - Springer
Abstract Apurinic/apyrimidinic endonuclease 1 (APE1), a ubiquitous multipurpose protein, is
also known as redox effector factor-1 (Ref-1). It is involved in DNA repair and redox …
also known as redox effector factor-1 (Ref-1). It is involved in DNA repair and redox …
Downregulation of UBE2Q1 is associated with neuronal apoptosis in rat brain cortex following traumatic brain injury
Aberrant functionality of the ubiquitin proteasome system (UPS) has been implicated in the
pathology of various neurological disorders. Although it has been reported that the …
pathology of various neurological disorders. Although it has been reported that the …