Relatively low levels of antioxidant enzymes and high oxygen metabolism result in formation
of numerous oxidized DNA lesions in the tissues of the central nervous system …

Traumatic brain injury (TBI) is a global health issue that affects at least 10 million people per
year. Neuronal cell death and brain injury after TBI, including apoptosis, inflammation, and …

Protein moonlighting is a phenomenon in which a single polypeptide chain can perform a
number of different unrelated functions. Here we present our analysis of moonlighting in the …

Abstract Guanylate binding protein 2 (GBP2) is one member of GBP family. Recently, GBP2
has been proposed to be a novel target of anti-cancer drugs. However, the role of GBP2 in …

Traumatic brain injury (TBI) treatment is a long-term process and requires repeated
medicine administration, which, however, can cause high expense, infection, and …

The early antecedents of cerebral palsy (CP) are unknown but are suspected to be due to
hypoxia-ischemia (HI). In our rabbit model of CP, the MRI biomarker, apparent diffusion …

Reactive oxygen species (ROS) are important contributors to the secondary injury cascade
following traumatic brain injury (TBI), and ROS inhibition has consistently been shown to be …

Copper is a nutritional trace element required for cell proliferation and wound repair.
Methods: To explore increased copper uptake as a biomarker for noninvasive assessment of …

Abstract Apurinic/apyrimidinic endonuclease 1 (APE1), a ubiquitous multipurpose protein, is
also known as redox effector factor-1 (Ref-1). It is involved in DNA repair and redox …

Aberrant functionality of the ubiquitin proteasome system (UPS) has been implicated in the
pathology of various neurological disorders. Although it has been reported that the …