Spinal cord injury (SCI) triggers neuroinflammation, and subsequently secondary
degeneration and oligodendrocyte (OL) death. We report that the alarmin interleukin (IL)− 1α …

It has been reported that several immune cells can release chromatin and granular proteins
into extracellular space in response to the stimulation, forming extracellular traps (ETs). The …

Spinal cord injury (SCI) causes the release of danger signals by stressed and dying cells, a
process that leads to neuroinflammation. Evidence suggests that inflammation plays a role …

Acute cerebrovascular disease can affect people at all stages of life, from neonates to the
elderly, with devastating consequences. It is responsible for up to 10% of deaths worldwide …

Background The blood–brain barrier (BBB) of the central nervous system (CNS) is essential
for normal brain function. However, the loss of BBB integrity that occurs after ischaemic …

Traumatic spinal cord injury (SCI) is a drama in two acts. The first part represents the trauma
itself, causing the destruction of neural tissue, ie, the elimination of neuronal and glial cells …

Acquired brain ischemia-and reperfusion-injury (IRI), including both Ischemic stroke (IS) and
Traumatic Brain injury (TBI), is one of the most common causes of disability and death in …

Aims Because of their prothrombotic and neuroinflammatory effects, neutrophils and
neutrophil extracellular traps (NETs) represent interesting therapeutic targets for …

Neutrophils are the most abundant leukocytes and usually the first immune cell-type
recruited to a site of infection or tissue damage. In asphyxiated neonates, elevated …

Neutrophils are the first line of defense in the innate immune system, helping to maintain
tissue homeostasis as well as eliminating pathogens and self-components. The traditional …