Polymorphonuclear neutrophil granulocytes (PMN) orchestrate the removal of cell debris in
ischemic stroke and intracerebral hemorrhage. In both pathologies, high neutrophil to …

Ischemia reperfusion (IR) injury results in devastating skeletal muscle fibrosis. Here, we
recapitulate this injury with a mouse model of hindlimb IR injury which leads to skeletal …

m6A modifications play an important role in the differentiation and regulation of immune
cells. However, research on m6A in ischaemic stroke (IS) is still in its infancy, and their role …

The peripheral immune system plays a critical role in neuroinflammation of the central
nervous system after an insult. Hypoxic-ischemic encephalopathy (HIE) induces a strong …

Streptococcus suis is a zoonotic agent causing meningitis in pigs and humans. Neutrophils,
as the first line of defense against S. suis infections, release neutrophil extracellular traps …

Cerebral ischemic injury, one of the leading causes of morbidity and mortality worldwide,
triggers various central nervous system (CNS) diseases, including acute ischemic stroke …

As a prototypical proinflammatory cytokine, interleukin-1 (IL-1) exacerbates the early post-
stroke inflammation, whereas its neutralization is protective. To further investigate the …

In ischemic stroke, neutrophils infiltrate damaged brain tissue immediately following the
ischemic insult and aggravate inflammation via various mechanisms which include …

Recently it was shown that the hematophagous salivary gland protein agaphelin exhibits
multiple antithrombotic effects without promoting the risk of bleeding. Agaphelin inhibits …

The purinergic P2X7 receptor (P2X7R) belongs to a family of trimeric ion channels that are
gated by extracellular adenosine 5′-triphosphate (ATP). Several studies have pointed to a …