Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease

M Hoenigl, A Arastehfar, MC Arendrup… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Fungal infections are on the rise, driven by a growing population at risk and climate change.
Currently available antifungals include only five classes, and their utility and efficacy in …

[HTML][HTML] Treatment of invasive aspergillosis: how it's going, where it's heading

J Boyer, S Feys, I Zsifkovits, M Hoenigl, M Egger - Mycopathologia, 2023 - Springer
Despite improvements in treatment and diagnostics over the last two decades, invasive
aspergillosis (IA) remains a devastating fungal disease. The number of …

[HTML][HTML] Fungal vaccine development: State of the art and perspectives using Immunoinformatics

MM Inácio, ALE Moreira, VRM Cruz-Leite, K Mattos… - Journal of Fungi, 2023 - mdpi.com
Fungal infections represent a serious global health problem, causing damage to health and
the economy on the scale of millions. Although vaccines are the most effective therapeutic …

Vaccine development for pathogenic fungi: current status and future directions

JL Chechi, FAC da Costa, JM Figueiredo… - Expert Review of …, 2023 - Taylor & Francis
Introduction Fungal infections are caused by a broad range of pathogenic fungi that are
found worldwide with different geographic distributions, incidences, and mortality rates …

TRAF3 gene regulates macrophage migration and activation by lung epithelial cells infected with Aspergillus fumigatus

S Shang, D He, C Liu, X Bao, S Han… - Microbiology …, 2024 - Am Soc Microbiol
Aspergillus fumigatus is an opportunistic pathogen that infects immunocompromised
patients and imposes a heavy burden on global health. Searching for key genes in host …

Fungal vaccines and adjuvants: a tool to reveal the interaction between host and fungi

Z Wang, J Shao - Archives of Microbiology, 2024 - Springer
Fungal infections are incurring high risks in a range from superficial mucosal discomforts
(such as oropharyngeal candidiasis and vulvovaginal candidiasis) to disseminated life …

Targeting Sterylglucosidase A to Treat Aspergillus fumigatus Infections

N Pereira de Sa, K Jayanetti, D Rendina, T Clement… - Mbio, 2023 - Am Soc Microbiol
Invasive fungal infections are a leading cause of death in immunocompromised patients.
Current therapies have several limitations, and innovative antifungal agents are critically …

A Fungal Sterylglucosidase at the Intersection of Virulence, Host Immunity, and Therapeutic Development

RA Cramer - Mbio, 2022 - Am Soc Microbiol
Human fungal infections (mycoses) cause significant morbidity and mortality in high-risk
populations. Contemporary antifungal therapies rely heavily on three classes of antifungal …

[HTML][HTML] Sterylglucosides in Fungi

N Pereira de Sa, M Del Poeta - Journal of Fungi, 2022 - mdpi.com
Sterylglucosides (SGs) are sterol conjugates widely distributed in nature. Although their
universal presence in all living organisms suggests the importance of this kind of glycolipids …