Gliomas are the common type of brain tumors originating from glial cells. Epidemiologically,
gliomas occur among all ages, more often seen in adults, which males are more susceptible …

The WHO 2007 glioma classification system (based primarily on tumour histology) resulted
in considerable interobserver variability and substantial variation in patient survival within …

To follow the revision of the fourth edition of WHO classification and the recent progress on
the management of diffuse gliomas, the joint guideline committee of Chinese Glioma …

Importance Per the World Health Organization 2016 integrative classification, newly
diagnosed glioblastomas are separated into isocitrate dehydrogenase gene 1 or 2 (IDH) …

The NCCN Guidelines for Central Nervous System (CNS) Cancers focus on management of
adult CNS cancers ranging from noninvasive and surgically curable pilocytic astrocytomas …

Glioma is often referred to as one of the most dreadful central nervous system (CNS)-specific
tumors with rapidly-proliferating cancerous glial cells, accounting for nearly half of the brain …

PURPOSE NRG Oncology/RTOG 9802 (ClinicalTrials. gov Identifier: NCT00003375) is a
practice-changing study for patients with WHO low-grade glioma (LGG, grade II), as it was …

Glioblastoma (GBM) is highly invasive and the deadliest brain tumor in adults. It is
characterized by inter-tumor and intra-tumor heterogeneity, short patient survival, and lack of …

Approximately half of glioblastoma and more than two-thirds of grade II and III glioma tumors
lack the DNA repair protein O6-methylguanine methyl transferase (MGMT). MGMT-deficient …

Temozolomide (TMZ) is a standard treatment for glioblastoma (GBM) patients. However,
TMZ has moderate therapeutic effects due to chemoresistance of GBM cells through less …