Scarring is part of the normal healing response to tissue injury in all organs and required to
rapidly repair acute damages, mostly with extracellular matrix. A variety of different cells are …

Myofibroblasts, and the extracellular matrix (ECM) in which they reside, are critical
components of wound healing and fibrosis. The ECM, traditionally viewed as the structural …

Chemical modifications of histones can mediate diverse DNA-templated processes,
including gene transcription,–. Here we provide evidence for a class of histone post …

Improper healing of the cornea after injury, infections or surgery can lead to corneal scar
formation, which is associated with the transition of resident corneal keratocytes into …

Keratohyalin granules were discovered in the mid-19th century in cells that terminally
differentiate to form the outer, cornified layer of the epidermis. The first indications of the …

Idiopathic pulmonary fibrosis (IPF) is characterized by accumulation of extracellular matrix
(ECM) proteins and fibroblast proliferation. ECM cross-linking enzymes have been …

Celiac disease (CD) is an increasingly common disease of the small intestine that occurs in
genetically susceptible subjects by ingestion of cereal gluten proteins. Gluten is highly …

The 3D bioprinting of stem cells directly into scaffolds offers great potential for the
development of regenerative therapies; in particular for the fabrication of organ and tissue …

Collagens form the fibrous component of the extracellular matrix in all multi-cellular animals.
Collagen type I is the most abundant collagen present in skin, tendons, vasculature, as well …

The biocatalytic activity of transglutaminases (TGs) leads to the synthesis of new covalent
isopeptide bonds (crosslinks) between peptide-bound glutamine and lysine residues, but …