Infertility is a common problem affecting one in six couples and in 30% of infertile couples,
the male factor is a major cause. A large number of genes are involved in spermatogenesis …

Recent pharmacogenomic/pharmacogenetic (PGx) studies have disclosed important roles
for drug transporters in the human body. Changes in the functions of drug transporters due …

Infertility is one of the most serious social problems facing advanced nations. In general,
approximate half of all cases of infertility are caused by factors related to the male partner …

Paeonol, a phenolic ingredient in the genus Paeonia, possesses antioxidant and anti-
inflammatory effects. Methotrexate (MTX) is a commonly used chemotherapeutic agent; …

Bisphenol A (BPA) engenders testicular toxicity via hydroxyl free radical genesis in rat
striatum and depletion of the endogenous antioxidants in the epididymal sperms. The multi …

The anticancer drug; doxorubicin (DOX), causes testicular toxicity as an adverse effect. P-
glycoprotein (P-gp) is a multidrug resistance efflux transporter expressed in blood-testis …

The multi-drug resistance 1 (MDR1) gene encodes for a P-glycoprotein (PGP), which acts as
a gate-keeper against various kinds of xenobiotics. Several single nucleotide …

Cadmium (Cd) has been reported to induce reproductive toxicity. Recent study indicated that
aberrant epigenetic regulation of Multidrug resistance 1b (Mdr1b) causes xenobiotic efflux …

Understanding the genetic basis of idiopathic male infertility has long been the focus of
many researchers. Numerous recent studies have attempted to identify relevant single …

В монографии представлен отечественный и зарубежный опыт планирования,
выполнения клинической и биоаналитической частей, а также обработки, анализа …