The intestinal barrier protects the host against gut microbes, food antigens, and toxins
present in the gastrointestinal tract. However, gut barrier integrity can be affected by intrinsic …

The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and
utilization, dependent on availability and requirement, is known as metabolic flexibility. In …

The outbreak of coronavirus disease (COVID-19) in late December 2019 in China, which
later developed into a pandemic, has forced different countries to implement strict sanitary …

In animal models, time-restricted feeding (TRF) can prevent and reverse aspects of
metabolic diseases. Time-restricted eating (TRE) in human pilot studies reduces the risks of …

Increased susceptibility of circadian clock mutant mice to metabolic diseases has led to the
idea that a molecular clock is necessary for metabolic homeostasis. However, these mice …

Antibiotic-induced microbiome depletion (AIMD) has been used frequently to study the role
of the gut microbiome in pathological conditions. However, unlike germ-free mice, the effects …

Abstract Circadian (∼ 24-hour) timing systems pervade all kingdoms of life and temporally
optimize behavior and physiology in humans. Relatively recent changes to our …

Introduction: Recent observations have shown that lengthening the daily eating period may
contribute to the onset of chronic diseases. Time-restricted eating (TRE) is a diet that …

Background Weight gain and obesity have reached alarming levels. Eating at a later clock
hour is a newly described risk factor for adverse metabolic health; yet, how eating at a later …

Compositional oscillations of the gut microbiome are essential for normal peripheral
circadian rhythms, both of which are disrupted in diet-induced obesity (DIO). Although time …