Pharmacokinetic-pharmacodynamic (PKPD) modeling and simulation has evolved as an
important tool for rational drug development and drug use, where developed models …

The success of antimicrobial therapy is determined by complex interactions between an
administered drug, a host, and an infecting agent. In a clinical situation, the complexity of …

Antimicrobial peptides (AMPs) are ancient and conserved across the tree of life. Their
efficacy over evolutionary time has been largely attributed to their mechanisms of killing. Yet …

There is a complex quantitative relationship between the concentrations of antibiotics and
the growth and death rates of bacteria. Despite this complexity, in most cases only a single …

Most drugs, with few notable exceptions, such as heparin, exert their effects not within the
plasma compartment but in defined target tissues into which drugs must be distributed from …

At the moment, the most common pharmacokinetic/pharmacodynamic (PK/PD) approaches
for anti-infective agents, such as time above MIC, Cmax/MIC and AUC24/MIC, rely on …

In the quest of ways for rationalizing and accelerating drug product development, integrated
pharmacokinetic/pharmacodynamic (PK/PD) concepts provide a highly promising tool …

Antimicrobial peptides (AMPs) and antibiotics reduce the net growth rate of bacterial
populations they target. It is relevant to understand if effects of multiple antimicrobials are …

Mathematical modeling of drug effects maximizes the information gained from an
experiment, provides further insight into the mechanisms of drug effects, and allows for …

In vitro pharmacodynamic (PD) models are used to obtain useful quantitative information on
the effect of either single drugs or drug combinations against bacteria. This review provides …