Impacts of oxidative stress and PI3K/AKT/mTOR on metabolism and the future direction of investigating fucoidan-modulated metabolism

JP Shiau, YT Chuang, YB Cheng, JY Tang, MF Hou… - Antioxidants, 2022 - mdpi.com
The critical factors for regulating cancer metabolism are oxidative stress and
phosphoinositide-3-kinase/AKT serine-threonine kinase/mechanistic target of the rapamycin …

Hijacking and rewiring of host CircRNA/miRNA/mRNA competitive endogenous RNA (ceRNA) regulatory networks by oncoviruses during development of viral …

MJ Kamali, M Salehi, M Mostafavi… - Reviews in medical …, 2024 - Wiley Online Library
A significant portion of human cancers are caused by oncoviruses (12%–25%). Oncoviruses
employ various strategies to promote their replication and induce tumourigenesis in host …

Non‐coding RNA‐associated competitive endogenous RNA regulatory networks: novel diagnostic and therapeutic opportunities for hepatocellular carcinoma

S Khashkhashi Moghadam… - Journal of cellular …, 2022 - Wiley Online Library
Hepatocellular carcinoma (HCC), as the most prevalent liver malignancy, is annually
diagnosed in more than half a million people worldwide. HCC is strongly associated with …

Circular RNA hsa_circ_0062682 binds to YBX1 and promotes oncogenesis in Hepatocellular Carcinoma

R Razpotnik, R Vidmar, M Fonović, D Rozman… - Cancers, 2022 - mdpi.com
Simple Summary Circular RNA (circRNA) have a role in carcinogenesis in different cancers,
also in hepatocellular carcinoma (HCC). The transcriptome analyses of HCC tumours …

Anticancer perspective of 6-shogaol: anticancer properties, mechanism of action, synergism and delivery system

Y Jia, X Li, X Meng, J Lei, Y Xia, L Yu - Chinese Medicine, 2023 - Springer
Cancer is a malignant disease that has plagued human beings all the time, but the treatment
effect of commonly used anticancer drugs in clinical practice is not ideal by reason of their …

The transcription factor ChREBP Orchestrates liver carcinogenesis by coordinating the PI3K/AKT signaling and cancer metabolism

E Benichou, B Seffou, S Topçu, O Renoult… - Nature …, 2024 - nature.com
Cancer cells integrate multiple biosynthetic demands to drive unrestricted proliferation. How
these cellular processes crosstalk to fuel cancer cell growth is still not fully understood. Here …

Porphyromonas gingivalis-odontogenic infection is the potential risk for progression of nonalcoholic steatohepatitis-related neoplastic nodule formation

S Sakamoto, A Nagasaki, M Shrestha, T Shintani… - Scientific Reports, 2023 - nature.com
Porphyromonas gingivalis (Pg), a major periodontal pathogen is a known risk factor for
various systemic diseases. However, the relationship between Pg and nonalcoholic …

[HTML][HTML] Loss of hepatic FTCD promotes lipid accumulation and hepatocarcinogenesis by upregulating PPARγ and SREBP2

S Wang, Y Zhou, R Yu, J Ling, B Li, C Yang, Z Cheng… - JHEP Reports, 2023 - Elsevier
Background & Aims Exploiting key regulators responsible for hepatocarcinogenesis is of
great importance for the prevention and treatment of hepatocellular carcinoma (HCC) …

Copine 1 predicts poor clinical outcomes by promoting M2 macrophage activation in ovarian cancer

B Sheng, B Zhao, Y Dong, J Zhang, S Wu, H Ji… - …, 2023 - academic.oup.com
Abstract Objective Copine 1 (CPNE1), a membrane-binding protein, influences the
prognosis of various cancers. According to cBioPortal, CPNE1 amplification is a prevalent …

[PDF][PDF] Zinc fingers and homeoboxes 2 is required for diethylnitrosamine‐induced liver tumor formation in C57BL/6 mice

J Jiang, C Turpin, G Qiu, M Xu, E Lee… - Hepatology …, 2022 - Wiley Online Library
Liver cancer, comprised primarily of hepatocellular carcinoma (HCC), is the third leading
cause of cancer deaths worldwide and increasing in Western countries. We previously …